Wanping Sun

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Our previous studies have shown that central administration of angiotensin II (ANG II) causes vasopressin release in the near-term fetus in utero as evidence that the hypothalamic-neurohypophysial system has relatively matured before birth. However, it is still unknown whether the vasopressin controlling centers have been functionally developed in younger(More)
Competition with endogenous dopamine (DA) is usually invoked to explain changes in [(11)C]raclopride binding observed after amphetamine administration in animals and humans. This account has recently been questioned because a number of inconsistencies have been reported that contradict it. In the present study, we investigated whether the decrease in(More)
The present study was done in order to determine whether dopamine internalizes D2 receptors in CHO cells and whether the high-affinity or the low-affinity state of the dopamine D2 receptor is associated with dopamine-induced internalization of dopamine D2 receptors. Using [3H]sulpiride to label D2Long receptors in CHO cells, it was found that dopamine(More)
The renin-angiotensin system plays an important role in cardiovascular control. Intracerebroventricular (i.c.v.) angiotensin (ANG) II causes a reliable pressor response in the fetus at 90% gestation. To determine the roles of brain AT1 and AT2 receptors in this response, the effects of the central AT1 and AT2 receptor antagonists losartan and PD123319 were(More)
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