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Mupirocin W, a novel pseudomonic acid produced by targeted mutation of the mupirocin biosynthetic gene cluster.
- S. M. Cooper, R. Cox, +5 authors Christopher M Thomas
- Chemistry, Medicine
- Chemical communications
- 22 February 2005
Mutation of the mupW gene in the mupirocin biosynthetic gene cluster in Pseudomonas fluorescens results in efficient production of a novel pseudomonic acid metabolite, mupirocin W, which lacks the… Expand
Shift to Pseudomonic acid B production in P. fluorescens NCIMB10586 by mutation of mupirocin tailoring genes mupO, mupU, mupV, and macpE.
- S. M. Cooper, Wanpen Laosripaiboon, +7 authors Christopher M Thomas
- Biology, Medicine
- Chemistry & biology
- 1 July 2005
Mupirocin, a polyketide-derived antibiotic from Pseudomonas fluorescens NCIMB10586, is a mixture of pseudomonic acids (PA) that target isoleucyl-tRNA synthase. The mup gene cluster encodes both type… Expand
Mupirocin W (I), a Novel Pseudomonic Acid Produced by Targeted Mutation of the Mupirocin Biosynthetic Gene Cluster.