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BACKGROUND Transient preceding brief ischemia provides potent cardioprotection against subsequent long ischemia, termed ischemic preconditioning. Here, we hypothesized that transient short-term hypertrophic stimulation would induce the expression of hypertrophy regression genes and render the heart resistant to subsequent hypertrophic stress, and slow the(More)
The gene ankyrin repeat domain 1 (Ankrd1) is an enigmatic gene and may exert pleiotropic function dependent on its expression level, subcellular localization and even types of pathological stress, but it remains unclear how these factors influence the fate of cardiomyocytes. Here we attempted to investigate the role of CARP on cardiomyocyte hypertrophy. In(More)
Fibroblast growth factor 23 (FGF23) has been reported to induce left ventricular hypertrophy, but it remains unclear whether FGF23 plays a role in cardiac fibrosis. This study is attempted to investigate the role of FGF23 in post-infarct myocardial fibrosis in mice. We noted that myocardial and plasma FGF23 and FGF receptor 4 were increased in mice with(More)
So So Sou ut uthe hern n M M Me edic ical al U Uni nive ers rsity, y, G Gua ang ngzhou o , , Ch hin ina a a; 2 Card rdio iovascul ul ula a ar D Div ivis ision, n, D Dep pt of f M Med e icine, Na Na Nati t o on onal al al C C Ce er ereb eb bra ra al l a an and d Ca a ard d diov va vas scul ul la ar ar C C Cen n nte ter r r, O O Osa saka k k , Ja Japa pa pan(More)
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