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Neuronal activity-dependent gene transcription is a key feature of long-lasting synaptic strengthening associated with learning and memory, as well as activity-dependent neuroprotection. To comprehensively determine the molecular alterations, we carried out genome-wide microarray analysis in cultured rat cortical neurons treated with specific(More)
Microelectrode arrays (MEAs) provide a means to investigate the electrophysiological behavior of neuronal systems through the measurements from neuronal culture preparations. Changes in activity patterns of neuronal networks are usually detected by applying neural chemicals. Because of the difficulties of fabricating the arrays, and the delicate and less(More)
The cell cycle plays a crucial role in many cellular physiological processes and has drawn an increasing interest in past decades. In the current study, we have developed a bioelectronic chip-based system capable of performing real-time dynamic analysis of the cell cycle in live cells via non-invasive cellular impedance sensing. The cells were cultured on(More)
Developing new methods and technologies in order to pattern neurons into regular networks is of utmost scientific interest in the field of neurological research. An efficient method here is developed for trapping neurons and constructing ordered neuronal networks on bioelectronic chips by using arrayed negative dielectrophoretic (DEP) forces. A special(More)
UNLABELLED Etiologic diagnoses of lower respiratory tract infections (LRTI) have been relying primarily on bacterial cultures that often fail to return useful results in time. Although DNA-based assays are more sensitive than bacterial cultures in detecting pathogens, the molecular results are often inconsistent and challenged by doubts on false positives,(More)
The accurate detection of mycobacterial species from isolates and clinical samples is important for pathogenic diagnosis and treatment and for disease control. There is an urgent need for the development of a rapid, simple, and accurate detection method. We established a biochip assay system, including a biochip, sample preparation apparatus, hybridization(More)
Autapse is an unusual type of synapse generated by a neuron on itself. The ability to monitor axonal growth of single neurons and autapse formation in three-dimensions (3D) may provide fundamental information relating to many cellular processes, such as axonal development, synaptic plasticity and neural signal transmission. However, monitoring such growth(More)
This study proposes a process-oriented, automatic, formative assessment model for small group learning based on complex systems theory using a small dataset from a technology-mediated, synchronous mathematics learning environment. We first conceptualize small group learning as a complex system and explain how group dynamics and interaction can be modeled(More)
MicroRNAs (miRNAs), a class of endogenous small noncoding RNAs in eukaryotes, have been recognized as significant regulators of gene expression through post-transcriptional mechanisms. To date, >2000 miRNAs have been identified in the human genome, and they orchestrate a variety of biological and pathological processes. Disruption of miRNA levels correlates(More)