Skip to search formSkip to main contentSkip to account menu
Distinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201A.
View on PubMed
Aminoethylenes: a tetrahedral intermediate isostere yielding potent inhibitors of the aspartyl protease BACE-1.
TLDR
The AE isostere class represents a promising advance in the development of BACE-1 inhibitors, and possesses enzymatic and cell assay IC(50)s of 26 nM and 180 nM, respectively.
View on PubMed
Novel Pactamycin Analogs Induce p53 Dependent Cell-Cycle Arrest at S-Phase in Human Head and Neck Squamous Cell Carcinoma (HNSCC) Cells
TLDR
It is demonstrated that pactamycin analogs TM-025 and TM-026 induce senescence and inhibit proliferation of HNSCC cells via accumulation in S-phase through possible contribution of p53.
View PDF
Capillary electrophoresis: novel tool for simmondsins analysis and its application to jojoba breeding
View via Publisher
Biosynthetic studies and genetic engineering of pactamycin analogs with improved selectivity toward malarial parasites.
View on PubMed
Deciphering Pactamycin Biosynthesis and Engineered Production of New Pactamycin Analogues
Pactamycin is an aminocyclopentitol‐derived natural product that has potent antibacterial and antitumor activities. Sequence analysis of an 86 kb continuous region of the chromosome from Streptomyces…
View on Wiley
Fragment-based discovery of nonpeptidic BACE-1 inhibitors using tethering.
TLDR
The ABP ligands represent a new type of nonpeptidic Bace-1 inhibitor motif that has not been described in the aspartyl protease literature and may serve as a starting point for the development of BACE-1-directed Alzheimer's disease therapeutics.
View on PubMed
Elucidation of Final Steps of the Marineosins Biosynthetic Pathway through Identification and Characterization of the Corresponding Gene Cluster
TLDR
This work presents the first experimentally supported scheme for biosynthesis of marineosin and provides a new biologically active molecule, premarineosin.
View on PubMed
Mutasynthesis of fluorinated pactamycin analogues and their antimalarial activity.
TLDR
A mutasynthetic strategy has been used to generate fluorinated TM-025 and TM-026, two biosynthetically engineered pactamycin analogues produced by Streptomyces pactum ATCC 27456, providing insights into the biosynthesis of 3-aminobenzoic acid in S. pactum.
View on PubMed
Stereospecific Synthesis of 23-Hydroxyundecylprodiginines and Analogues and Conversion to Antimalarial Premarineosins via a Rieske Oxygenase Catalyzed Bicyclization
TLDR
This study presents the first example of oxidative bicyclization mediated by a Rieske oxygenase, a key step in the tailoring process of the biosynthesis of marineosins, using a marG heterologous expression system.
View on PubMed
...
...
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License