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It has been proposed that the reorganization of components of the actin cytomatrix could contribute to force development and the low energy cost of sustained contraction in contractile cells which lack a structured sarcomere (A.S. Battistella-Patterson, S. Wang and G.L. Wright (1997) Can J Physiol Pharmacol 75: 1287–1299). However, there has been no direct(More)
 Rat aortic rings maintained in organ culture for as little as 24 h show significant loss of contractile responsiveness to different agonists. Smooth muscle cells (SMC) in culture quickly de differentiate into a non-contractile phenotype with a marked capacity for proliferation. Rat aortic ring segments cultured in retinol supplemented (10–6 M) medium(More)
The subcellular translocation of PKCα was studied in A7r5 cells by confocal microscopy through use of standard immunohistologic staining and PKCα-enhanced green fluorescent protein (PKCα–EGFP) fusion protein expression. The results from both methods were consistent in indicating that PKCα, observed to be diffusely distributed in the unstimulated cell, was(More)
Salvianolic acid Y (TSL 1), a new phenolic acid with the same planar structure as salvianolic acid B, was isolated from Salvia officinalis. The structural elucidation and stereochemistry determination were achieved by spectroscopic and chemical methods, including 1D, 2D-NMR (1H-1H COSY, HMQC and HMBC) and circular dichroism (CD) experiments. The(More)
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