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Tuberculosis remains second only to HIV/AIDS as the leading cause of mortality worldwide due to a single infectious agent. Despite chemotherapy, the global tuberculosis epidemic has intensified because of HIV co-infection, the lack of an effective vaccine and the emergence of multi-drug-resistant bacteria. Alternative host-directed strategies could be(More)
BACKGROUND Coronary heart disease (CHD) mortality is rising in many developing countries. We examined how much of the increase in CHD mortality in Beijing, China, between 1984 and 1999 could be attributed to changes in major cardiovascular risk factors and assessed the impact of medical and surgical treatments. METHODS AND RESULTS A validated, cell-based(More)
To effectively realize the image feature matching for geomorphic reverse measurement and rebuilding, a new matching scheme is presented, where the SIFT method are adopted to implement initial geomorphic image matching by going through five stages: scale-space construction, scale-space extrema detection, orientation assignment, keypoint descriptor and(More)
BACKGROUND We studied the operation rate for secondary displacement in Garden type 1 femoral neck fracture when treated primarily conservatively. METHODS We reviewed the records of 115 patients with Garden type 1 femoral neck fractures primarily treated conservatively. RESULTS Operation for secondary displacement was required in 48 cases (41%); the(More)
Abnormalities in amygdala activity have been implicated in adolescents and older adults with major depressive disorder (MDD), but few studies have focused on young adults with early-onset MDD. In this study, we measured amygdala activity in 27 young adults with early-onset MDD and 25 healthy controls (HC) using functional magnetic resonance imaging (fMRI)(More)
Resistance to cisplatin is the main reason for treatment failure in ovarian cancer. Apoptosis is the main mechanism of action of most cancer chemotherapeutic agents. The apoptosis-associated proteins expressed in cisplatin-sensitive (A2780, COC1) and -resistant (A2780/DDP, COC1/DDP) ovarian cancer cell lines, as well as their effects on caspase-3 activity(More)
To validate whether down-regulation of microRNA-203 (miR-203) in hepatocellular carcinoma (HCC) is involved in HCC progression by targeting survivin. MiR-203 mimics was transfected into HepG2 cells to enhance miR-203 expression, and miR-203 inhibitor was transfected into HepG2 cells to inhibit miR-203 expression. The effect of up-regulation and(More)
OBJECTIVES/HYPOTHESIS To evaluate the effects of long-term denervation on satellite cells (SCs) as myogenic stem cells in human posterior cricoarytenoid (PCA) muscle. STUDY DESIGN Histological investigation of SCs and quantitative assessment of myoD and myogenin, which are two key myogenic regulatory factors. METHODS According to the course of(More)
1. There is growing evidence of the beneficial effects of hepatocyte growth factor (HGF) in myocardial infarction, heart failure and occlusive peripheral arterial disease. The aim of the present study was to evaluate the effects of intracoronary administration of an adenovirus vector encoding the human HGF gene (Ad-HGF) on serum levels of cytokines and(More)