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OBJECTIVE To analyse the five-point tuberculosis (TB) strategy, DOTS, 10 years after its implementation in one-half of China's population, and to suggest lessons for future implementation of the DOTS strategy. METHODS We analysed trends in case-finding and treatment outcome over time following implementation of the DOTS strategy in each county, using(More)
To identify issues relevant to nationwide implementation, a project was conducted during 1999-2001 to support and evaluate the development of a case-based measles surveillance system (MSS) in Shandong and Henan provinces, China. The performance of MSS surveillance and the descriptive characteristics of reported measles cases and outbreaks were analyzed. Of(More)
Measles incidence decreased dramatically following widespread use of measles vaccine in China in 1965. To evaluate continued progress in accelerated measles control, data on measles cases reported to the National Notifiable Disease Reporting System during 1991 to 2000 were analyzed. From 1991-1995 to 1996-2000, average annual measles incidence decreased(More)
Cre recombinase from bacteriophage P1 is widely used in both in vitro and in vivo DNA manipulations. Based on a structural and functional analysis, three deleted cre mutants were constructed and expressed in Escherichia coli. Mutated recombinases were purified and their recombination activities were determined in vitro. Our results revealed that the mutant(More)
OBJECTIVE To investigate the cost-effectiveness of a comprehensive programme for drug-resistant tuberculosis launched in four sites in China in 2011. METHODS In 2011-2012, we reviewed the records of 172 patients with drug-resistant tuberculosis who enrolled in the comprehensive programme and we collected relevant administrative data from hospitals and(More)
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