Wang-Ju Hsieh

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Tubulointerstitial nephritis is a main renal manifestation caused by pathogenic leptospira that accumulate mostly in the proximal tubules, thereby inducing tubular injury and tubulointerstitial nephritis. To elucidate the role of leptospira outer membrane proteins in tubulointerstitial nephritis, outer membrane proteins from pathogenic Leptospira shermani(More)
Chronic inflammation leads to a progressive inflammation in certain types of cells. Recent studies report that the activation of nuclear factor kappa B (NF-κB) increases the expression of inflammation-related protein such as inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2), which further enhance the chronic inflammation, thus conduct the(More)
Tensin family members, including tensin2 (TNS2), are present as major components of the focal adhesions. The N-terminal end of TNS2 contains a C1 region (protein kinase C conserved region 1) that is not found in other tensin members. Three isoforms of TNS2 have been identified with previous reports describing the shortest V3 isoform as lacking the C1(More)
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