• Publications
  • Influence
Cystic fibrosis transmembrane conductance regulator is vital to sperm fertilizing capacity and male fertility
  • W. Xu, Q. Shi, H. Chan
  • Biology
    Proceedings of the National Academy of Sciences
  • 5 June 2007
TLDR
CFTR in sperm may be involved in the transport of HCO3− important for sperm capacitation and that CFTR mutations with impaired CFTR function may lead to reduced sperm fertilizing capacity and male infertility other than CBAVD.
Molecular mechanisms of kinesin-14 motors in spindle assembly and chromosome segregation
TLDR
This Commentary presents the common subthemes that have emerged from studies of the molecular kinetics and mechanics of kinesin-14 motors, particularly with regard to their non-processive movement, their ability to crosslink microtubules and interact with the minus- and plus-ends of micro Tubules, and with microtubule-organizing center proteins.
C-Terminal Kinesin Motor KIFC1 Participates in Acrosome Biogenesis and Vesicle Transport1
TLDR
Data support a model in which KIFC1, perhaps in association with nuclear factors, assists in the formation and/or elongation of the spermatid acrosome, the formation of which is essential for fertilization.
Nanoparticles and spermatogenesis: how do nanoparticles affect spermatogenesis and penetrate the blood-testis barrier.
TLDR
In general, most NPs display adverse effects on spermatogenesis at these various levels; but, some NPs show no adverse effects; and many hypotheses for experimental testing are raised in order to elucidate the mechanism.
Multiple signaling pathways in Sertoli cells: recent findings in spermatogenesis
TLDR
Clarifying the mechanisms of signaling pathways in Sertoli cells on spermatogenesis provides new insights into the physiological functions of SERToli cells in male reproduction, and also serves as a pre-requisite to identify potential therapeutic targets in abnormal sperMatogenesis including testicular tumor and male infertility.
...
...