Wan Ting Tay

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We conducted a meta-analysis of genome-wide association studies of systolic (SBP) and diastolic (DBP) blood pressure in 19,608 subjects of east Asian ancestry from the AGEN-BP consortium followed up with de novo genotyping (n = 10,518) and further replication (n = 20,247) in east Asian samples. We identified genome-wide significant (P < 5 × 10−8)(More)
We conducted a three-stage genetic study to identify susceptibility loci for type 2 diabetes (T2D) in east Asian populations. We followed our stage 1 meta-analysis of eight T2D genome-wide association studies (6,952 cases with T2D and 11,865 controls) with a stage 2 in silico replication analysis (5,843 cases and 4,574 controls) and a stage 3 de novo(More)
PURPOSE To describe the prevalence and risk factors of diabetic retinopathy in Asian Malays. DESIGN Population-based cross-sectional study. PARTICIPANTS Persons with diabetes of Malay ethnicity aged 40 to 80 years in Singapore. METHODS Diabetes mellitus was defined as random glucose of 11.1 mmol/l or more, use of diabetic medication, or a physician(More)
PURPOSE To describe the association between refractive errors, ocular biometry, and age-related macular degeneration (AMD) in an Asian Malay population in Singapore. METHODS A population-based study of 3280 Malay individuals aged 40 to 80 years was conducted in Singapore. Early- and late-AMD signs were graded from retinal photographs according to the(More)
PURPOSE To examine the distribution and systemic determinants of ocular biometry as measured using partial laser interferometry in an adult Asian population. METHODS A population-based, cross-sectional study of 3280 persons (78.7% participation rate) ages 40 to 80 years, of Malay ethnicity residing in Singapore, was conducted. Axial ocular dimensions,(More)
OBJECTIVE The present study examined the effects of blood pressure on a spectrum of quantitative and qualitative retinal microvascular signs. METHODS Retinal photographs from the Singapore Malay Eye Study, a population-based cross-sectional study of 3280 (78.7% response) persons aged 40-80 years, were analyzed. Quantitative changes in the retinal(More)
PURPOSE Eyes with myopia may be less likely to develop diabetic retinopathy (DR). The relationship between refractive error, ocular biometry, and DR therefore was investigated. DESIGN Population-based, cross-sectional study. PARTICIPANTS Persons with diabetes from the Singapore Malay Eye Study (SiMES). METHODS Diabetes mellitus was defined as random(More)
INTRODUCTION This study highlights the key epidemiological findings from the Singapore Malay Eye Study (SiMES-1). METHODS SiMES-1 was a cross-sectional, population-based epidemiological study on eye diseases. It was performed on 3,280 randomly selected Malay adults living in the south-western part of Singapore. All study participants underwent various(More)
PURPOSE C-reactive protein (CRP) is an inflammatory biomarker that may be associated with diabetic retinopathy (DR), but body mass index (BMI) is an important confounder of this relationship. The purpose of this study was to determine the relationship between CRP, BMI, and existing DR. METHODS This was a population-based, cross-sectional study on 718(More)
PURPOSE Polypoidal choroidal vasculopathy (PCV) has been described as a distinct clinical entity from choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD). The present study aimed to determine risk factors for PCV and to compare associations with those for CNV secondary to AMD. DESIGN Case-control study. PARTICIPANTS(More)