Wan-Ching Yang

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MicroRNAs (miRNAs) play critical roles in embryonic development and are frequently deregulated in human cancers. The let-7 family members are tumor-suppressing miRNAs and are frequently downregulated in cancer cells. Lin-28 and Lin-28B are RNA-binding proteins highly expressed in embryonic tissues. Lin-28 proteins block let-7 precursors from being processed(More)
AIMS Chromophobe renal cell carcinoma (ChRCC) is an uncommon malignant renal neoplasm with a generally indolent clinical behaviour. Previous studies revealed biallelic inactivation of the hepatocyte nuclear factor-1β (HNF1β) gene in several patients with ChRCC. The aims of this study were to determine HNF1β expression in renal neoplasms and the potential of(More)
Lin-41 is a stem cell-specific E3 ligase and a known target of the tumour suppressor microRNA (miRNA) let-7. Lin-41 was recently reported to mediate ubiquitylation and degradation of the miRNA pathway protein Ago2. We demonstrate that Lin-41 is over-expressed in hepatocellular carcinoma (HCC). Lin-41 over-expression correlates with high α-fetoprotein level,(More)
A search for the production of neutral Higgs bosons decaying into ττ final states is presented in pp̄ collisions at a center-of-mass energy of 1.96 TeV. The integrated luminosity used for the study is about 2.2 fb, collected by the DØ Experiment at the Fermilab Tevatron Collider. No significant excess is observed over the background expectation. The results(More)
Viral hepatitis-associated intrahepatic cholangiocarcinoma is thought to have common disease processes with hepatocellular carcinoma, but until now the histomorphological and genetic features of viral hepatitis-associated intrahepatic cholangiocarcinoma is still unknown. From 2000 to 2010, 170 patients with intrahepatic cholangiocarcinoma who received(More)
The split pickup and delivery problem is to find the shortest route that can provide delivery nodes with commodities collected from pickup nodes, subject to the vehicle load constraint. In particular, the split feature allows multiple visits to nodes and thus enables the vehicle to load or discharge an arbitrary portion of commodities along the route. This(More)
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