Wan-Chen Ku

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Stem cells of the corneal epithelium have been found to be located exclusively at the anatomical junction between the cornea and the conjunctiva, the limbus. Ex vivo expanded limbal epithelial cells on amniotic membrane (AM) are capable of restoring the corneal surface with limbal stem cell deficiency. Recent studies indicate that intact AM preserves the(More)
PURPOSE To investigate the expression and pivotal role of matrix metalloproteinase (MMP)-9 in the ex vivo expansion of human limbal explants with or without amniotic membrane (AM). METHODS Corneoscleral buttons were cultured on intact, denuded AM or plastic dishes for 3 weeks. To determine the role of MMP-9 in cell migration, either the MMP inhibitor(More)
BACKGROUND This retrospective study was conducted to analyze the progression rates of diabetic retinopathy (DR) after phacoemulsification in diabetic patients and to determine whether phacoemulsification causes the progression of DR. METHODS The medical charts of diabetic patients who had undergone cataract surgery using phacoemulsification techniques(More)
PURPOSE The most common ocular adverse event following the use of cyclosporine A (CsA) 0.05% ophthalmic emulsion is ocular burning (17%). Other adverse effects that have been reported include conjunctival hyperemia (1-5%), discharge, epiphora, eye pain, foreign body sensation, pruritus, stinging and blurred vision. Here, we report a specific side effect of(More)
BACKGROUND To determine the outcome of central retinal vein occlusion (CRVO) in pre-existing glaucoma and the predisposing factors of developing neovascular glaucoma (NVG). METHODS We retrospectively assessed a pre-existing glaucoma CRVO group and a non-glaucoma CRVO group to elucidate the demographics, clinical course and ocular parameters of these two(More)
PURPOSE To elucidate the relationship between the severity of vitreous haemorrhage (VH) and visual outcome in primary rhegmatogenous retinal detachment (RRD) without previous vitreoretinal surgery. METHODS We carried out a retrospective review of patients presenting with RRD and VH between January 1993 and December 2002. Diabetic retinopathy, retinal(More)
BACKGROUND To evaluate the efficacy of internal limiting membrane (ILM) peeling in the treatment of a macular hole. METHODS The ocular evaluation included Snellen visual acuity, a slit-lamp examination, indirect ophthalmoscopy, and contact lens biomicroscopy. The macular holes were confirmed using a Watzke-Allen slit beam test. Surgery consisted of a(More)
PURPOSE To evaluate secondary ocular hypertension after intravitreal injection of triamcinolone acetonide (IVTA) with 2 mg/0.05 mL or 4 mg/0.1 mL for macular edema associated with retinal vein occlusion (RVO). METHODS A retrospective chart review was performed. Patients with RVO, including central RVO and branch RVO, were divided into 2 groups. Group 1(More)
PURPOSE To assess the safety and efficacy of phacoemulsification under a topical anesthesia combined with intracameral lidocaine 0.5%. SETTING Department of Ophthalmology, Chang Gung Memorial Hospital, Taoyuan, Taiwan, China. METHODS A prospective randomized double-blind study was designed in which patients had phacoemulsification performed under(More)
BACKGROUND According to the high prevalence of myopia in Taiwan, we analyze the adopted cataract extractions, identify predicting factors for postoperative vision, and to assess the incidence of retinal complications after Nd: YAG laser capsulotomy in high myopic eyes. METHODS One hundred and twenty-five eyes, which the axial lengths were longer than 26(More)