Walthard Vilser

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PURPOSE Subtle changes in retinal vascular caliber have been shown to predict diabetic retinopathy and other diabetic complications. This study was undertaken to investigate whether retinal vascular caliber correlates with light-flicker-induced retinal vasodilation, a measure of endothelial function. METHODS The participants were 224 persons with diabetes(More)
OBJECTIVE Flicker light-induced retinal vasodilation may reflect endothelial function in the retinal circulation. We investigated flicker light-induced vasodilation in individuals with diabetes and diabetic retinopathy. RESEARCH DESIGN AND METHODS Participants consisted of 224 individuals with diabetes and 103 nondiabetic control subjects. Flicker(More)
PURPOSE The present study investigated whether age, blood pressure (BP), and baseline vessel diameter influence the retinal arterial response to flicker light. METHOD Thirty healthy subjects (mean age, 46.3; range, 22-73 years) and 15 patients with untreated essential arterial hypertension (mean, 50.9; range, 26-69 years) were examined. The diameter of(More)
PURPOSE Luminance flicker stimulation of the photoreceptors is known to increase retinal blood flow. Elevated blood velocity was determined using laser Doppler velocimetry, and increased vascular diameters during flicker were observed by measurements with a retinal vessel analyzer. Oxygen supply may be the target of the regulation of retinal blood flow.(More)
AIM To investigate diameter changes in retinal arterioles in response to flicker variations of the examination light. METHODS One randomised eye of five healthy subjects (mean age 33.8 (SD 1.6) years) was examined. The arterial diameter response to flicker light (12.5 Hz, 530-600 nm, duration 20 seconds) was automatically and continuously measured online(More)
PURPOSE To determine whether retinal branch arteries of healthy persons in different age groups show different longitudinal vessel profiles at baseline and during dynamic reaction to flicker stimulation. METHODS Thirty-three healthy subjects (age groups: 21-27 years, 40-59 years, and 60-85 years) were examined with the use of a retinal vessel analyzer. A(More)
PURPOSE It was demonstrated previously that retinal pulse wave velocity (rPWV) as a measure of retinal arterial stiffness is increased in aged anamnestically healthy volunteers compared with young healthy subjects. Using novel methodology of rPWV assessment this finding was confirmed and investigated whether it might relate to the increased blood pressure(More)
We present a novel non-invasive and non-contact system for reflex-free retinal imaging and dynamic retinal vessel analysis in the rat. Theoretical analysis was performed prior to development of the new optical design, taking into account the optical properties of the rat eye and its specific illumination and imaging requirements. A novel optical model of(More)
Ischaemia, loss of neural tissue, glial cell activation and tissue remodelling are symptoms of anterior ischaemic as well as glaucomatous optic neuropathy leading to pallor of the optic nerve head. Here, we describe a simple method for the pallor measurement using a fundus camera equipped with a colour CCD camera and a special dual bandpass filter. The(More)
PURPOSE To determine the effects of surgical IOP reduction (trabeculectomy) on retinal blood flow parameters in glaucoma patients using Dynamic Vessel Analysis (DVA). METHODS 26 eyes of 26 patients with progressive primary open-angle glaucoma (POAG) despite maximal topical therapy were examined before and after trabeculectomy. The responses of the retinal(More)