The catalogue of design patterns from [Gamm94] contains about twenty design patterns and their mutual relationships. In this paper, we organize these relationships into different categories and revise the design patterns and their relationships. We are then able to arrange the design patterns in different layers. The results simplify the understanding of… (More)
This paper gives an overview of the OBST persistent object management system. OBST has been developed by the Forschungszentrum Informatik (FZI) as a contribution to the STONE project. 1 The paper summarizes the design objectives and the current status of OBST, and highlights forthcoming developments with the system.
Hyperhomocysteinemia is a risk factor for obstructive large-vessel disease. Here, we studied plasma concentrations of homocysteine and vitamins in patients suffering from subcortical vascular encephalopathy (SVE), a cerebral small-vessel disease leading to dementia. These results were compared to the homocysteine and vitamin plasma concentrations from… (More)
PURPOSE We examined the relationship between human leukocyte antigen (HLA) matching and the development of cyclosporine (CyA) neurotoxicity in patients undergoing allogeneic bone marrow transplantation, and determined the frequency and imaging characteristics of CyA neurotoxicity in these patients. METHODS Records of 87 patients who underwent allogeneic… (More)
Most current object-oriented design techniques and approaches focus on the new development of a software system, without regarding the reorganization of existing systems at all. But many people point out, that after the initial design and implementation of an object-oriented system, the system must often be reorganized in order to get a cleaner design which… (More)
Coherent design is a design method for object-oriented software development. It reconciles the requirements of extensibility, comprehensibility, and efficiency for designing reusable libraries. It does so by applying the following principles: separation of behaviour and implementation, compatibility relationships between classes, and conceptual abstraction.… (More)
The existence of poly(A) sequences in the multiple high molecular weight forms of ovalbumin and ovomucoid nuclear RNA has been determined. The results indicate that all the bands observed in the total nuclear RNA including the largest (7.8 kb) were also detected in the poly(A) RNA. Kinetic labeling and chase experiments in oviduct tissue-suspension system… (More)