Walter Reinisch

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BACKGROUND Infliximab, a chimeric monoclonal antibody directed against tumor necrosis factor alpha, is an established treatment for Crohn's disease but not ulcerative colitis. METHODS Two randomized, double-blind, placebo-controlled studies--the Active Ulcerative Colitis Trials 1 and 2 (ACT 1 and ACT 2, respectively)--evaluated the efficacy of infliximab(More)
BACKGROUND The comparative efficacy and safety of infliximab and azathioprine therapy alone or in combination for Crohn's disease are unknown. METHODS In this randomized, double-blind trial, we evaluated the efficacy of infliximab monotherapy, azathioprine monotherapy, and the two drugs combined in 508 adults with moderate-to-severe Crohn's disease who(More)
The second European evidence-based Consensus on the diagnosis and management of Crohn's disease: Special situations Gert Van Assche ⁎, Axel Dignass ⁎, Walter Reinisch, C. Janneke van der Woude, Andreas Sturm, Martine De Vos, Mario Guslandi, Bas Oldenburg, Iris Dotan, Philippe Marteau, Alessandro Ardizzone, Daniel C. Baumgart, Geert D'Haens, Paolo(More)
OBJECTIVE The aim of this study was to assess the efficacy and safety of adalimumab (ADA), a recombinant human monoclonal antibody against tumour necrosis factor α (TNF), for the induction of clinical remission in anti-TNF naïve patients with moderately to severely active ulcerative colitis. METHODS This 8-week, multicentre, randomised, double-blind,(More)
Second European evidence-based consensus on the diagnosis and management of ulcerative colitis Part 2: Current management Axel Dignass ⁎, James O. Lindsay, Andreas Sturm, Alastair Windsor , Jean-Frederic Colombel , Mathieu Allez , Gert D'Haens, André D'Hoore, Gerassimos Mantzaris , Gottfried Novacek , Tom Öresland, Walter Reinisch, Miquel Sans, Eduard(More)
Citation for published version: Rahier, JF, Magro, F, Abreu, C, Armuzzi, A, Ben-Horin, S, Chowers, Y, Cottone, M, de Ridder, L, Doherty, G, Ehehalt, R, Esteve, M, Katsanos, K, Lees, CW, Macmahon, E, Moreels, T, Reinisch, W, Tilg, H, Tremblay, L, Veereman-Wauters, G, Viget, N, Yazdanpanah, Y, Eliakim, R, Colombel, JF & on behalf of the European Crohn's and(More)
service Email alerting top right corner of the article Receive free email alerts when new articles cite this article sign up in the box at the Topic collections (195 articles) Changing physician behavior • (493 articles) Guidelines • (717 articles) Inflammatory bowel disease • (277 articles) Gastro-esophageal reflux • (252 articles) Gastrointestinal(More)
The management of patients with IBD requires evaluation with objective tools, both at the time of diagnosis and throughout the course of the disease, to determine the location, extension, activity and severity of inflammatory lesions, as well as, the potential existence of complications. Whereas endoscopy is a well-established and uniformly performed(More)