Walter M St -John

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This study evaluated possible neuronal mechanisms responsible for the transition from normal breathing (eupnea) to gasping. We hypothesized that a blockade of both inhibitory glycinergic synaptic transmission and potassium channels, combined with an increase in extracellular concentration of potassium, would induce a switch from an eupneic respiratory(More)
During eupnea in an in situ perfused preparation of the rat, inspiratory activities of the hypoglossal and vagal nerves commence before the phrenic; the vagus also discharges in expiration. The hypoglossal discharge has a prominent "pre-inspiratory" component. Power spectral analysis indicated that peak frequencies of oscillations in phrenic, hypoglossal(More)
The perfused in situ juvenile rat preparation produces phrenic discharge patterns comparable to eupnea and gasping in vivo. These ventilatory patterns of eupnea and gasping differ in multiple aspects, including most prominently the rate of rise of inspiratory activity. Because gasping, but not eupnea, appeared similar after vagotomy in spontaneous breathing(More)
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