Walter. M. Gregory

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BACKGROUND There is no clear data on the optimum number of courses of platinum chemotherapy required for treating advanced ovarian cancer. A prospective randomised trial was performed to compare five with eight courses of either carboplatin 400 mg/m2 or cisplatin 75 mg/m2 given four-weekly to patients with stage IC-IV ovarian cancer. PATIENTS AND METHODS(More)
PURPOSE The progression of keratoconus to a stage where penetrating keratoplasty (PK) is required for visual rehabilitation has considerable implications for affected patients. To assist with counselling, the authors have attempted to identify which factors measurable early in the course of the disease may indicate the likelihood of subsequent surgery. (More)
PURPOSE To determine the effect of bilateral surgery on the rejection-free survival of penetrating keratoplasties (PK) performed for keratoconus. METHODS The records of 587 patients with a PK for keratoconus who attended a single center over a 7-year period were reviewed. Details on 400 patients were sufficiently complete to permit a multivariate analysis(More)
ee front matter & 2005 bmt.2004.12.003 ng author. Tel.: +1 503 Summary Objective: Patients who have fibromyalgia syndrome (FMS) associated with cervical spine trauma have distinct pain descriptors and physical examination findings. Currently, there is no effective treatment for fibromyalgia. Microamperage current provides physiologic current flow and has(More)
We looked for continued corneal ectasia after penetrating keratoplasty (PK) for keratoconus by measuring long-term changes in keratometry and refraction after final suture removal. The records of 587 patients who had had PK for keratoconus and who had attended a single center over a 7-year period were examined. For 184 eyes keratometry or refraction data(More)
PURPOSE To determine in a randomized trial of advanced ovarian carcinoma whether consolidation therapy with whole-abdominal radiotherapy (RT) after chemotherapy improves survival and disease-free survival compared with the continued chemotherapy. PATIENTS AND METHODS Two hundred fifty-four patients with advanced epithelial ovarian cancer (stages IIB to(More)
PURPOSE To determine the clinical factors associated with the development of acute corneal hydrops and its subsequent outcome. METHODS The authors identified 147 eyes (124 patients) with acute hydrops from a database of 5242 eyes (2723 patients) with keratoconus. They compared the clinical features of patients in whom hydrops developed with unaffected(More)
The prognostic value of biological, clinical and laboratory features was analysed in a series of 265 patients with chronic lymphocytic leukaemia (CLL) and prolymphocytic leukaemia (PLL). On univariate analysis seven features were shown to influence significantly the survival of the whole group of patients: absolute prolymphocyte count (ABS PROL), percentage(More)
The objective was to assess the long-term survival (5-15 years) in 463 women, with stages IIb-IV epithelial carcinoma of the ovary and to compare their survival with that of a normal population matched for age and sex. Statistical analysis of 463 women, with stages IIb-IV epithelial cancer of the ovary, who were participants in two consecutive North Thames(More)
BACKGROUND Stage I non-small cell lung cancer (NSCLC) is potentially curable, and surgery is considered to be the standard of care for patients with good performance status and minimal co-morbidity. However, a significant proportion of patients with stage I NSCLC have a poorer performance status and significant medical co-morbidity that make them at higher(More)