Walter J van Dijk

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An in vivo model for perfusion chemotherapy of the rat hind limb is described in which perfusion at a predetermined flow rate of up to 4 ml.min-1 can be rapidly established in a tourniquet-isolated limb. Standard additions to the semisynthetic perfusion medium included glucose, insulin, and lactate from fresh human erythrocytes. Arteriovenous differences in(More)
The light chain ratios and the concentrations of immunoglobulin G (IgG), IgA, and IgM were measured before, during, and after antileukemic therapy in 10 patients with common acute lymphoblastic leukemia. The concentrations of IgG, IgA, and IgM decreased substantially during treatment but recovered slowly after cessation of the therapy. The light chain(More)
In an in vivo model for isolated limb perfusion, developed previously, adriamycin was observed to induce tumors, mainly rhabdomyosarcomas. The tumor incidence was dose dependent. A low incidence was observed after a pseudophysiological perfusion at low flow rate (LF) and 0.25 hematocrit (LF.25). The drug disappearance from the perfusate at the tumorigenic(More)
Due to more stringent requirements to protect personnel against hazardous gasses, the inspiratory resistance of the present generation of respiratory protective devices tends to increase. Therefore an important question is to what extent inspiratory resistance may increase without giving problems during physical work. In this study the effects of three(More)