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Advances in computational network analysis have enabled the characterization of topological properties in large scale networks including the human brain. Information on structural networks in the brain can be obtained in-vivo by performing tractography on diffusion tensor imaging (DTI) data. However, little is known about the reproducibility of network(More)
BACKGROUND AND PURPOSE Findings of blood oxygen level-dependent (BOLD) functional MR (fMR) imaging of the cervical spinal cord, obtained by using a fist-clenching motor task, have been sporadically reported. Because spinal activation by sensory stimuli has a potential at least equal to that of fist clenching, its feasibility was assessed. Whether(More)
Although it is known that responses in the auditory cortex are evoked predominantly contralateral to the side of stimulation, the lateralization of responses at lower levels in the human central auditory system has hardly been studied. Furthermore, little is known on the functional interactions between the involved processing centers. In this study,(More)
PURPOSE Impaired memory performance is the most frequently reported cognitive problem in patients with chronic epilepsy. To examine memory deficits many studies have focused on the role of the mesiotemporal lobe, mostly with hippocampal abnormalities. However, the role of the prefrontal brain remains unresolved. To investigate the neuronal correlates of(More)
In functional MRI experiments on the central auditory system, activation caused by acoustic scanner noise is a dominating factor that partially masks the hemodynamic response signals to sound stimuli of interest. In this study, the nonlinear interaction between auditory responses to single scans and those to tone stimuli was investigated. By using irregular(More)
BACKGROUND An often underestimated cognitive morbidity in patients with epilepsy is language dysfunction. To investigate the neuronal mechanisms underlying neuropsychological language impairment, activation maps and functional connectivity networks were studied by fMRI of language. METHOD Fifty-two patients with cryptogenic localization-related epilepsy(More)
INTRODUCTION Rolandic epilepsy (RE) is an idiopathic focal childhood epilepsy with a well-established neuropsychological profile of language impairment. The aim of this study is to provide a functional correlate that links rolandic (sensorimotor) pathology to language problems using functional MRI. MATERIALS AND METHODS Twenty-three children with RE (8-14(More)
OBJECTIVE Psychogenic non-epileptic seizures (PNES) are epilepsy-like episodes which have an emotional rather than organic origin. Although PNES have often been related to the process of dissociation, the psychopathology is still poorly understood. To elucidate underlying mechanisms, the current study applied independent component analysis (ICA) on(More)
Our aim was to put together and test a comprehensive functional MRI (fMRI) protocol which could compete with the intracarotid amytal (IAT) or Wada test for the localisation of language and memory function in patients with intractable temporal lobe epilepsy. The protocol was designed to be performed in under 1 h on a standard 1.5 tesla imager. We used five(More)
OBJECTIVE To study the relation between possibly altered whole brain topology and intellectual decline in chronic epilepsy, a combined study of neurocognitive assessment and graph theoretical network analysis of fMRI was performed. METHODS Forty-one adult patients with cryptogenic localization-related epilepsy and 23 healthy controls underwent an(More)