Walter Ernst

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To study the established but not well understood phenomenon of improved intratreatment vascular stability during hemofiltration the same 10 stable hemodialysis patients were investigated during one hemodialysis and one hemofiltration treatment. Both treatments were matched in regard to linear fluid withdrawal (3 kg/240 minutes), small molecule removal rate(More)
High pretransplantation sCD30 levels have been shown to be associated with lower 5-year kidney graft survival in mainly Cyclosporine A (CsA)-treated recipients (Collaborative Transplant Study database). To analyze the effect of different immunosupressive regimens (CsA/Azathioprine [Aza], CsA/Mycophenolate Mofetil [MMF], Tacrolimus [Tacr]/Aza) on sCD30, we(More)
Plasma concentrations of noradrenaline (NA), adrenaline (A) and renin (R) were measured in 29 regular haemodialysis patients (RHP) [13 normotensive, 10 hypertensive, 6 binephrectomised] and in 15 healthy control subjects (C) under various physiological conditions: supine-standing-walking. RHP had significant higher plasma levels of noradrenaline and(More)
In 12 RDT patients the volume removal related haemodynamic changes were correlated with concomitant changes in sympathetic activity during pure ultrafiltration (UF), post dilution haemofiltration (HF) and haemodialysis using either acetate (HDA) or bicarbonate (HDB) as buffer substitute. Total peripheral resistance (TPR) and plasma noradrenaline(More)
Sympathetic and hemodynamic response to a constant volume removal was investigated during pure ultrafiltration, hemofiltration, acetate hemodialysis, and bicarbonate hemodialysis in the same ESRD patients. Small solute removal rates were matched. The sympathetic response resulting in an increase of total peripheral vascular resistance was found to be(More)
The vast majority of grafts with acute vascular rejection (AVR) undergoes irreversible loss of function, since this type of rejection usually does not respond to increased immunosuppression. Since 1980 we have treated in 22 patients 27 steroid resistant AVR by plasmafiltration (PF). Per episode 6 x 5 L plasma were filtered and simultaneously replaced by(More)
Long-term studies strongly suggest that tight control of blood glucose achieved by conventional intensive insulin treatment, self-blood glucose monitoring and patients education can significantly prevent the development and retard the progression of chronic complications of type-1 diabetes mellitus [1, 2]. However, the expense for this benefit was a(More)
Immunological monitoring for chronic allograft nephropathy (CAN) is of great potential interest. We assessed serum soluble CD30 (sCD30) together with in vitro Th2-type responses (IL-4, IL-10, CD4 helper activity) and neopterin in a prospective study of 84 renal transplant recipients with 2-year follow-up. Patients were randomized to CsA/Aza, CsA/MMF and(More)
We have previously shown that high pretransplant regulatory autoantibodies are associated with better kidney graft outcome. To analyze the effect of intravenous immunoglobulin (IVIG) induction therapy on these regulatory antibodies, we performed a prospective randomized study in 50 renal transplant recipients who were randomly assigned to receive 7 x 10 g(More)