Walter Englaro

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The peroxisome proliferator–activated receptor ␥ (PPAR ␥) is highly expressed in the colon mucosa and its activation has been reported to protect against colitis. We studied the involvement of PPAR ␥ and its heterodimeric partner, the retinoid X receptor (RXR) in intestinal in-flammatory responses. PPAR ␥ ϩ / Ϫ and RXR ␣ ϩ / Ϫ mice both displayed a(More)
The peroxisome proliferator-activated receptor gamma (PPARgamma) is highly expressed in the colon mucosa and its activation has been reported to protect against colitis. We studied the involvement of PPARgamma and its heterodimeric partner, the retinoid X receptor (RXR) in intestinal inflammatory responses. PPARgamma(1/)- and RXRalpha(1/)- mice both(More)
Up-regulation of the cAMP pathway by forskolin or alpha-melanocyte stimulating hormone induces melanocyte and melanoma cell differentiation characterized by stimulation of melanin synthesis and dendrite development. Here we show that forskolin-induced dendricity is associated to a disassembly of actin stress fibers. Since Rho controls actin organization, we(More)
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