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Parkinson's disease involves impaired activation of frontal cortical areas, including the supplementary motor area and prefrontal cortex, resulting from impaired thalamocortical output of the basal ganglia. Electrophysiologically, such impaired cortical activation may be seen as a reduced amplitude of the contingent negative variation (CNV), a slow negative(More)
In light of artifact-induced high variability of activation in fMRI repeat studies, we developed and tested a clinically useful plaster cast head holder (PCH) with improved immobilization, repositioning, and comfort. With PCH, there were considerably lower levels of translational and rotational head motion components compared to head fixation with(More)
We assessed serial event-related potentials (ERPs) as well as neuropsychological and clinical test findings in a group of multiple sclerosis (MS) patients (n = 14) treated with interferon beta-1b (INF-beta-1b) compared to normal controls (n = 14). All investigations were done within 1 week before INF-beta-1b therapy was started and 12 months later. An(More)
The EEG activity preceding self-paced voluntary movements (movement-related cortical potential, MRCP) is smaller if subjects make the same movement each time (regular task) compared with when different movements are made each time (random task). To test whether extra activity in the random task is due to increased motor preparation needed to switch between(More)
Event-related brain potentials (ERPs) were used to investigate the time course of memory processes following the presentation of faces. Following a phase in which subjects were asked to memorize faces presented on a computer screen (study phase) they had to distinguish the previously presented faces from others new to the experiment (test phase). We found(More)
OBJECTIVE We investigated early brain activity (under 200 ms after the stimulus onset) related to the encoding and the retrieval of verbal information. METHODS First, we compared ERPs produced by words which were encoded to ERPs produced by words from following test phases (correctly identified repetitions and correctly classified new words) in two(More)
OBJECTIVE The contingent negative variation (CNV) is a widespread electroencephalographic (EEG) potential that occurs during the interval between a warning stimulus and a subsequent imperative stimulus if a mental or motor response is required. The present study was designed to explore the impact of the previous trial on the CNV of the forthcoming trial,(More)
Brain potentials were recorded from 15 healthy young subjects during the performance of a word recognition task. During the study phase, subjects had to intentionally memorise a series of words. These words were presented again together with the same number of new words in a following test phase where the instruction was to discriminate between repeated(More)
In a recognition memory experiment we recorded event-related brain potentials (ERPs) following the presentation of faces. We compared correctly classified repetitions of faces (hits) with new faces classified as repeated (false alarms). Stimulus-related averaging yielded significantly more negative ERPs to false alarms between 750 and 900 ms after onset of(More)
First, we recorded brain potentials from 15 healthy young subjects during the performance of a word/non-word discrimination task. During continuous visual presentation, some of the meaningful words were repeated after 86-94 s. We found a significant decrease of response time associated with the classification of repeated words which is an index for priming,(More)