Walter E van den Brom

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The pathogenesis of congenital portosystemic shunt (CPSS) in dogs still is incompletely understood. In Irish Wolfhounds and Yorkshire Terriers, CPSS is reported to be hereditary. The aim of this study was to investigate a possible genetic basis and the mode of inheritance of CPSS in Cairn Terriers. Between July 1990 and July 2001, 6-week-old pups of the(More)
Two studies were conducted under laboratory conditions with 16 dogs to investigate the analgesic effectiveness of a low dose of ketoprofen in a short-term sodium urate crystal-induced synovitis model of arthritis. The effect of the treatment, defined as the improvement in peak vertical force weight bearing was evaluated in the first study at three dose(More)
OBJECTIVE To evaluate the long-term outcome after decompressive surgery in dogs with degenerative lumbosacral stenosis (DLS), using force plate analysis (FPA) and owner questionnaires. STUDY DESIGN Prospective clinical study. ANIMALS Dogs with DLS (n=31) and 24 clinically normal Labrador Retrievers. METHODS FPA was performed before surgery (31 dogs)(More)
The variation in the duration of gestation, defined as the period from mating to parturition, was studied in 113 bitches of six breeds (31 Dobermans, 31 Labrador retrievers, 14 German shepherds, 13 Bernese mountain dogs, 12 golden retrievers and 12 West Highland white terriers). The bitches were mated once on the optimal day for mating, which was(More)
The sensitivity of the hypothalamic-pituitary-adrenal system in pigeons (Columba livia domestica) to glucocorticoid feedback was studied after single intravenous administration of dexamethasone (500, 100, 50, 10, 5, 1, 0.5, and 0.1 micrograms/kg), cortisol (15,000, 3000, 1500, 300, 150, 30, 15, and 3 micrograms/kg), and prednisolone (3500, 700, 350, 70, 35,(More)
To standardise the method of eliciting somatosensory-evoked potentials (SEPs), SEPs were generated by electrical stimulation of different stimulus sites and recorded bilaterally from the primary somatosensory cortex (S1) and from midline in awake, freely moving rats. Increasing stimulus intensity enhanced amplitudes of all SEPs. At supramaximal stimulation,(More)
The somatosensory-evoked potential (SEP) elicited by high-intensity stimulation potentially provides a reliable indicator of analgesic efficacy since it reflects the level of activation of the nociceptive system. In the present study, components in the 10-30-ms latency range of SEPs recorded over the primary somatosensory cortex (SI-SEPs) and vertex(More)
For the determination of specific gravity of canine urine the urinometer is often used. An alternative method is based on refractometry. Both methods were compared and a table for converting refractometer values to urinometer values is given. The refractometer was also compared with an osmometer. A linear relation was found between the readings of both(More)
Thyroidal 99mTcO4- (pertechnetate) uptake percentages were determined in unanesthetized euthyroid (n = 13) and hyperthyroid (n = 18) cats. Maximal uptakes were observed 60 minutes after IV injection of the radionuclide and ranged from 0.3 to 3.9% of the dose in euthyroid cats (median 2.23%) and from 5.2% to 23.9% of the dose in hyperthyroid cats (median(More)
Cranium and brainstem dimensions were measured in 32 postmortem dog heads. Positive correlations were found between cranium length (CL) and brainstem length (BL) (r = 0.87), between cranium width (CW) and brainstem width (BW) (r = 0.83), and between cranium distance (CD = CL+CW/2) and brainstem distance (BD = BL+BW/2) (r = 0.91). Positive correlation(More)