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Administration of gangliosides has been reported to stimulate regeneration of motoneurons and of central dopaminergic and cholinergic neurons. To shed light on the mechanism by which gangliosides mediate the effects on cholinergic neurons, we studied their actions on cultures of cells dissociated from the septal area of fetal rat brains. These cultures(More)
Throughout the 20 th century, science fiction portrayed a robotic future in both utopian and dystopian ways. The reality of automated systems, intelligent systems, and " robots " in the workforce, however, is much more mundane, even if it is undoubtedly disruptive. The same set of technologies that empower employees to be more effective or bear less(More)
Presented below is a list of recent journal articles and technical documents that discuss statistical models for predicting beach water quality. These articles provide a scientific foundation for the development and testing of predictive beach water quality models. Use of predictive models and rapid methods to nowcast bacteria levels at coastal beaches. and(More)
em feature The development of ecological forecasts, namely, methodologies, to predict the chemical, biological, and physical changes in terrestrial and aquatic ecosystems is desirable so that effective strategies for reducing the adverse impacts of human activities and extreme natural events can be developed to sustain ecosystem productivity. The temporal(More)
The central dopaminergic effects of an abeorphine derivative 201-678 were compared to those of apomorphine and bromocriptine in different model systems. After oral administration, this compound induced contralateral turning in rats with 6-hydroxydopamine induced nigral lesions and exhibited strong anti-akinetic properties in rats with 6-hydroxydopamine(More)
[3H]205-501, a noncatechol dopaminergic agonist, is presented as a ligand with high affinity (KD approximately 1 nM) and high selectivity for dopamine receptors. pKi values of dopaminergic agonists derived from competition isotherms in the [3H]205-501 binding assay correlate very well with their potency in the acetylcholine release assay, which is(More)
Acute administration of MPTP (a synthetic heroin substitute) at 10-30 mg/kg (s.c.) produced 'Straub tail' phenomena, piloerection and reduced pelvis elevation in rats. The same dose decreased the concentrations of dopamine metabolites and reduced the rate of dopamine synthesis in the striatum. MPTP also reduced the metabolism of serotonin but accelerated(More)
[3H]Quinuclidinylbenzilate (QNB) was used to identify muscarinic cholinergic receptors on intact, cultured neurons from fetal rat brains. Scatchard analysis revealed a single binding site with a dissociation constant Kd = approximately or equal to 170 pM. The rank order of potency of cholinergic drugs to displace [3H]QNB from intact neurons was similar to(More)
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