Learn More
A reappraisal of survival data on patients with uveal melanomas has led us to these impressions: (a) that the mortality rate before enucleation is low, estimated at 1% per year; (b) that the mortality rate rises abruptly following enucleation, reaching a peak of about 8% during the second year after enucleation; and (c) that approximately two-thirds of the(More)
Two hundre seventeen small malignant melanomas, each with a volume less than 1,400/cu mm, were studied to determine what factors were useful in predicting metastasis. Using a single-factor approach with 16 risk factors, we found seven that correlated well with outcome. These were cell type, pigmentation, size (largest dimension), scleral extension, mitotic(More)
The dry mass of individual vaccinia virions, as an example of a presumably uniform biological population, prepared in different lost at the Institute for Tropical Hygiene in Hamburg, was tested for variability by quantitative electron microscopy. A value of 5.26 X 10(-15) g for the median weight of the particle was calculated from 7,300 determinations. By(More)
One hundred well-documented cases of uveal melanoma accessioned at the Armed Forces Institute of Pathology before 1970 were reviewed and reclassified to identify changes made in the Callender classification. We compared the new classification with the original classification to determine the effect of the changes on the prediction of outcome for the patient(More)
We have observed that the fatality rate of patients with posterior uveal melanomas rapidly increased from a very low rate prior to enucleation to a maximum of 8% per year during the second year after enucleation. These data suggest to us that events related to enucleation have a deleterious effect on survival, and we have postulated that these events are(More)
Myoadenylate deaminase deficiency is believed to reflect a genetic deficiency of skeletal muscle, but its pattern of inheritance has not been established. We examined, histochemically and by quantitative biochemical assay, muscle biopsy specimens from 3 putative carriers of this disorder. Adenylate kinase and creatine kinase were assayed in parallel with(More)
Reappraisal of follow-up data obtained on patients whose uveal melanomas were treated by enucleation before 1955 has led to the conclusion that the operation may have had an adverse effect, accelerating dissemination and a lethal outcome, especially among patients whose tumors were large and/or contained epitheloid cells. The temporal relationship of tumor(More)