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The urinary excretion of D-glucaric acid reflects the activity of hepatic enzymes that hydroxylate and detoxify many substances foreign to the body. We measured it in 38 healthy unmedicated males (ages, 3 to 90 years; weights 11.8 to 136 kg) and in 15 females (ages, 10 to 80). The males, regardless of age or weight, excreted 56.1 ±15.7 (SD) nmol of(More)
PURPOSE To describe the MR appearance of the olfactory bulbs and tracts and temporal lobes in patients with Kallmann syndrome, a disorder characterized by hypogonadotropic hypogonadism and anosmia. METHODS High-resolution MR scans with a surface coil placed over the nasion were performed in two patients with Kallmann syndrome. Coronal 3-mm thick(More)
The precise cause of Ménière disease remains unclear. Multiple causes have been proposed with most experimental evidence pointing to impaired fluid resorption by the endolymphatic duct and sac as the final common pathway in development of hydrops. We report a unique case of Ménière disease secondary to compression of the endolymphatic duct and sac by an(More)
Evidence is presented for the occurrence of a locus for schizotaxia on the short arm of chromosome 6. This derives from study of 63 informative members of seven pedigrees in which the proband and a parent (or a sib of parent) suffered with schizophrenia and other kin were either normal or fell within a spectrum of conditions related to schizophrenia. For(More)