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Design and synthesis of some novel quinoline derivatives as anticancer and radiosensitizing agents targeting VEGFR tyrosine kinase
Quinoline derivatives posses many types of biological activities and have been reported to show significant anticancer activity. There is a variety of mechanisms for the anticancer activity and theExpand
Novel brominated quinoline and pyrimidoquinoline derivatives as potential cytotoxic agents with synergistic effects of γ-radiation
The most potent compounds 6, 14 and 19 were evaluated for their ability to enhance the cell killing effect of γ-radiation and exhibited better activity than doxorubicin. Expand
Design, synthesis and molecular modeling study of certain 4-Methylbenzenesulfonamides with CDK2 inhibitory activity as anticancer and radio-sensitizing agents.
Two series of 2-aminopyridine derivatives 6-17 and tyrphostin AG17 analogs 18-22 bearing 4-methylbenzenesulfonamide moiety were designed and synthesized as anticancer compounds and showed the best activities against human breast cancer cell line MCF-7. Expand
Design and Synthesis of Some Novel Quinoline Derivatives as Anticancer and Radiosensitizing Agents Targeting VEGFR Tyrosine Kinase.
A variety of novel quinoline and pyrimidoquinoline derivatives (XVI) is synthesized from enaminone (I), and evaluated for in vitro effects against the human cancer cell line MCF7.