Waldemar Szaroma

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One of the major classes of ionotropic glutamate receptors is the class of N-methyl-D-aspartate receptors (NMDARs). Receptor activation recruits, via calcium signal transduction mechanisms which play important roles in oxidative metabolism, mitochondrial free radical production and occurrence of other mitochondrial factors which potentially contribute to(More)
The karyometric analysis of the cells of the pineal gland and subcommissural organ in Rana temporaria L. was carried out under the influence of dehydration in the annual cycle. The dehydration stress was found to retard the activity of the pineal gland and at the same time to stimulate the activity of the subcommissural organ apart from the breeding period(More)
The effect of acute exposure of intraperitoneal injection of kainic acid (KA) on the activity of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSHPx), amount of reduced glutathione (GSH) and content of ascorbic acid (ASC) has been studied in brain, liver and kidneys of male mice. Animals (n = 144) were treated KA with one dose, i.e. 12(More)
Reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSHPx) are vital components of the antioxidative barrier in animal cells. It is suggested more often now that the effectiveness of the protection of cells against the oxidative stress caused by the inflammation process depends on the amount of GSH and the(More)
The influence of a single dose of ACTH(100 I.U. /kg body weight) on the diurnal rhythm of reduced glutathione (GSH) was studied in the blood and brain, liver and kidney homogenates of male mice. Cosinor analysis revealed that ACTH induces changes in the mean diurnal amount of GSH in the blood, brain, liver and kidneys. At the same time, GSH amplitudes in(More)
Sexually mature male and female Rana temporaria L. of similar body length were captured in their natural habitat in seven stages of the annual cycle. Each stage included one control and two experimental groups of frogs exposed to dehydration. Measurements of cytoplasmic RNA in the neurocytes of the preoptic nucleus (PON) were done by a(More)
Sodium nitroprusside (SNP) is an antihypertensive drug with proven dose-dependent toxic effects attributed mainly to the production of cyanide but also excesive nitric oxide (NO) and derived reactive species. The present study evaluated whether melatonin administration would have time-dependent protective effect against SNP−induced toxicity. Male Swiss mice(More)
The influence of a single dose of actinomycin-D (1 mg/kg body weight) on the diurnal rhythm of cytoplasmic RNA was studied in neurocytes of the supraoptic nucleus (SON), paraventricular nucleus (PVN), and arcuate nucleus (AN) by microspectrophotometer. Cosinor analysis of the obtained results revealed a disturbed diurnal rhythm of cytoplasmic RNA in the(More)
Intraperitoneal injections of mercuric acetate or lead acetate in doses of 0.2 mg daily during 14 and 21 days caused statistically significant rise in the number of the Gomori-positive glial cells around the third cerebral ventricle of mice. In addition, the nuclei of the Gomori-positive glial cells markedly increased in volume.