Wakako Yamada

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RATIONALE The interaction of receptor for advanced glycation end products (RAGE) and its ligands often leads to inflammatory processes or tissue injury, although the effect of the blockade of RAGE signaling on lung injury remains to be investigated. OBJECTIVES Using a murine model of lung injury induced by intratracheal lipopolysaccharide (LPS), we(More)
We made a solid three-dimensional object of the Redies-Spillmann figure and found two kinds of completely different phenomena. First, transparent color-spreading was observed in the empty space around the object. Second, another perceptual organization occurred: observers perceived a cross as a cross-shaped slit through which to see, and then they perceived(More)
BACKGROUND Vascular endothelial growth factor (VEGF), a substance that stimulates new blood vessel formation, is an important survival factor for endothelial cells. Although overexpressed VEGF in the lung induces pulmonary edema with increased lung vascular permeability, the role of VEGF in the development of acute lung injury remains to be determined. (More)
BACKGROUND Toll-like receptors (TLRs) represent a conserved family of innate immune recognition receptors. Among TLRs, TLR4 is important for the recognition of Gram-negative bacteria, whereas TLR2 recognizes cell wall constituents of Gram-positive microorganisms, such as peptidoglycan (PGN). METHODS To evaluate the role of TLR4 in the pathogenesis of(More)
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