Wai-Ting Nicola Lee

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Liver toxicity is a well recognised side-effect of endothelin receptor antagonists (ERAs) (bosentan, sitaxentan and ambri-sentan) and long-term monthly monitoring of liver function tests (LFTs) is mandatory. Sitaxentan is thought to be less commonly associated with liver toxicity compared with the older agent bosentan and has been used as an alternative in(More)
BACKGROUND Haemodynamic measurements may be superior to the 6-min walk distance (6MWD) as outcome measures in pulmonary hypertension (PH) as they are directly linked to the mechanisms of disease and are not subject to a ceiling effect. The aim of this study was to determine if treatment response in precapillary PH could be detected by pulmonary blood flow(More)
Contemporary prognostic equations in pulmonary arterial hypertension (PAH) derived from US and French cohorts may not perform as well in the UK as a locally derived scoring scheme. The aim of the study was to develop and validate a UK risk score to predict prognosis in PAH. Baseline mortality predictors identified by multivariate Cox analysis in 182(More)
Absolute 6-min walk distance (6MWD) predicts mortality in pulmonary arterial hypertension (PAH), but varies greatly between normal individuals due to physiological factors such as age, sex, height and weight. The % predicted 6MWD adjusts for these factors and may predict mortality more reliably. The aim of the study was to compare the strength of mortality(More)
REFERENCES 1 Stolz D, Rasch H, Linka A, et al. A randomised, controlled trial of bosentan in severe COPD. Eur Respir J 2008; 32: 619–628. 2 Humbert M, Sitbon O, Simonneau G. Treatment of pulmonary arterial hypertension. N Engl J Med 2004; 351: 1425–1436. 3 Rietema H, Holverda S, Bogaard HJ, et al. Sildenafil treatment in COPD does not affect stroke volume(More)
A 34-year-old woman with atopic asthma since the age of 16 years presented with increasing exertional dyspnoea and wheeze over a period of 12 months. She had no symptomatic benefit from escalation of bronchodilator therapy and her peak expiratory flow (PEF) remained reduced despite multiple courses of oral corticosteroid. Lung function at rest showed mild(More)
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