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The importance of voltage-dependent Ca2+ channels (VDCCs) in pain transmission has been noticed gradually, as several VDCC blockers have been shown to be effective in inhibiting this process. In particular, the N-type VDCC has attracted attention, because inhibitors of this channel are effective in various aspects of pain-related phenomena. To understand(More)
alpha(1) subunit of the voltage-dependent Ca(2+) channel is essential for channel function and determines the functional specificity of various channel types. alpha(1E) subunit was originally identified as a neuron-specific one, but the physiological function of the Ca(2+) channel containing this subunit (alpha(1E) Ca(2+) channel) was not clear compared(More)
Thalamic haemorrhage is usually considered a single entity although the thalamus is composed of anatomically as well as functionally discrete subregions receiving blood from different arteries. The clinical features vary according to the intrathalamic location of the haematomas and the bleeding artery. We investigated the impact of haematoma location and(More)
Social and genetic factors can influence smoking behavior. Using olfactogustatory stimuli as the sensory cue for intravenous nicotine self-administration (SA), we previously showed that social learning of nicotine contingent odor cue prevented rats from developing conditioned taste aversion and allowed them to instead establish stable nicotine SA. We(More)
Bystander effects induced by cytoplasmic irradiation have been reported recently. However, the mechanism(s) underlying, such as the functional role of mitochondria, is not clear. In the present study, we used either mtDNA-depleted (rho(0)) A(L) or normal (rho(+)) A(L) cells as irradiated donor cells and normal human skin fibroblasts as receptor cells in a(More)
Chronic hyperglycemia causes a progressive decrease of β-cell function and mass in type 2 diabetic patients. Growing evidence suggests that augment of autophagy may be an effective approach to protect β cells against various extra-/intracellular stimuli. In this study, we thus investigated whether bone marrow-derived mesenchymal stem cells (BM-MSCs) could(More)
BACKGROUND This study explored the association between smoking and colorectal malignant carcinoma (CRC) in the Chinese population at the national level for the first time. METHODS In the China Nationwide Retrospective Mortality Survey conducted during 1989-1991, 12,942 CRC cases among 1,136,336 all-cause deaths aged ≥30 years were randomly assigned 25,884(More)
" Factorbird-a parameter server approach to distributed matrix factorization, " in NIPS Workshop on Distributed Matrix Computations, 2014. A fast parallel SGD for matrix factorization in shared memory systems, NOMAD: Non-locking, stochastic multi-machine algorithm for asynchronous and decentralized matrix completion, " in VLDB, " Scalable coordinate descent(More)
OBJECTIVE To study a new positioning method of elbow external fixation rotation axis, and to evaluate its feasibility. METHODS Four normal adult volunteers and six Sawbone elbow models were brought into this experiment. The kinematic data of five elbow flexion were collected respectively by optical positioning system. The rotation axes of the elbow joints(More)
Acknowledgments I would like to express my sincere gratitude to my two Co-Directors: Shih-Chun Chang and Shu Lin without whom this would not be possible. In addition, I would especially like to thank Shu Lin for his encouragement, his creativity and his generosity, all of which are an inspiration to me. A special thanks to my entire family who provided much(More)