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OBJECTIVE To carry out a comprehensive field investigation to evaluate various conventional and recently developed biomarkers for exposure to low concentrations of benzene. METHODS Analyses were carried out on environmental air, unmetabolised benzene in blood and urine, urinary trans, transmuconic acid, and three major phenolic metabolites of benzene:(More)
Reports on cases of Stevens-Johnson syndrome (erythema multiforme major) have seldom related it to occupational exposure to chemicals. Serious liver involvement is also uncommon. This report describes 5 cases of the syndrome who had been occupationally exposed to trichloroethylene. The circumstantial evidence suggested that the chemical might have been a(More)
Tinnitus is said to be a common complaint of workers who are exposed to noise. We studied the prevalence and characteristics of tinnitus in 647 noise-exposed workers who had been notified as cases of noise-induced deafness. One hundred and fifty-one had tinnitus, giving a prevalence of 23.3 per cent. The tinnitus was bilateral in 42.4 per cent of cases, and(More)
Spirometry, chest radiography, environmental measurements, and a questionnaire on respiratory symptoms were used to evaluate the effects of exposure to polyvinyl chloride (PVC) dust on 171 Chinese and Malay PVC compounding workers in comparison with an unexposed reference group. Workers with high cumulative PVC dust exposure had a lower forced expiratory(More)
OBJECTIVES To investigate the risk factors predicting radiological progression in silicosis in a prospective cohort study of patients with silicosis who were previously exposed to silica from granite dust. METHODS From among a total of 260 patients with silicosis contracted from granite work, 141 with available serial chest x ray films of acceptable(More)
It has previously been shown that granite workers with heavy exposure to silica had glomerular and proximal tubular dysfunction evidenced by increased urinary excretions of albumin, alpha-1-microglobulin (AMG), and beta-N-acetyl-glucosaminidase (NAG). The investigation was replicated in another group of granite workers to further elucidate the exposure(More)
This report presents baseline findings from the first of a series of epidemiological studies to evaluate inter alia the effects of control measures introduced in 1972-79 to reduce dust exposure in all quarries in Singapore. The prevalence of radiological abnormalities among 219 currently employed quarry workers were estimated according to a number of(More)
The purpose was to determine if solderers had increased diurnal variation (DV) in peak expiratory flow rate (PEFR) and chronic impairment of lung function. A cross-sectional study of 150 female operators doing manual soldering using flux-cored (rosin-based) solder wire and 52 administrative staff from two electronics factories was carried out. They answered(More)