Wael F Farrag

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Cytogenetic aberrations are important prognostic factors in acute myeloid leukemia (AML). About 45% of de novo AML lack cytogenetic abnormalities, so identification of predictive molecular markers might improve therapy. We studied the prognostic impact of brain and acute leukemia, cytoplasmic (BAALC) and ETS-related gene (ERG) expression in AML with normal(More)
Several genetic studies were carried out among hypertensive patients to assess allelic association at the 1166 position of the 3' untranslated region of angiotensin II type 1 receptor gene. In addition, attempts have also been made to find out whether telomere length attrition is associated with hypertension. The main aim of this study was to examine the(More)
BACKGROUND The underlying mechanisms of hepatitis C virus (HCV) resistance to treatment are unknown. Signal transducers and activators of transcription (STAT) proteins play a critical role in antiviral defense. OBJECTIVE To explore some of the mechanisms of HCV resistance to interferon, the expression of STAT1 and its negative regulators, protein(More)
Reduced nicotinamide adenine dinucleotide phosphate [NAD(P)H] oxidase is an important source of superoxide (O2-) in human blood vessels. A critical component of this oxidase is the p22phox protein, which is encoded by the cytochrome b-245 α (CYBA) gene. Studies have suggested a possible association between polymorphisms of the CYBA gene and susceptibility(More)
BACKGROUND AND STUDY AIMS Mannan-binding lectin (MBL) is a collectin synthesised in the liver and secreted into the bloodstream. It binds micro-organisms via interactions with glycans on the target surface. Bound MBL subsequently activates MBL-associated serine protease proenzymes (MASPs). Several studies have investigated the possible role for MBL in(More)
Chronic myeloid leukemia (CML) is characterized by formation of the BCR/ABL fusion gene. The response to therapy may vary because of development of secondary cytogenetic changes or resistance. In addition, suppressor of cytokine signalling (SOCS) proteins is also hypothesized as a cause of resistance and poor prognosis when aberrantly overexpressed. This(More)
AIM Mast cells are found to be an important contributor in obesity induced insulin resistance. We evaluate the effect of ketotifen in obese patient with type 2 diabetes (T2DM) treated with glimepiride. METHOD In a randomized controlled study we recruited forty-eight obese patients with T2DM from Internal Medicine Department at Tanta University Hospital,(More)
OBJECTIVES To detect relative frequency of anaplastic lymphoma kinase (ALK-1) gene abnormality in diffuse large cell lymphoma (DLCL) using fluorescence in situ hybridization (FISH), and correlate its presence with clinicopathological features which may be useful for choice of therapy and predict survival in newly diagnosed cases. PATIENTS AND METHODS A(More)
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