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BACKGROUND/AIMS Inhibition of hepatoma cells by cyclooxygenase (COX)-2-dependent and -independent mechanisms has been shown previously. Here, we examine the effect of Celecoxib, a COX-2-inhibitor and R-Etodolac, an enantiomer of the nonsteroidal anti-inflammatory drug Etodolac, which lacks COX-inhibitory activity, on the Wnt/beta-catenin pathway and human(More)
From sunspot drawings provided by the Kanzelhöhe Solar Observatory, Austria, and the Skalnaté Pleso Observatory, Slovak Republic, we extracted a data catalogue of hemispheric Sunspot Numbers covering the time span 1945–2004. The validated catalogue includes daily, monthly-mean, and smoothed-monthly relative sunspot numbers for the northern and southern(More)
Although the role of Wnt/beta-catenin signaling in liver growth and development is well established, its contribution in non-neoplastic hepatic pathologies has not been investigated. Here, we examine the role of beta-catenin in a murine model of diet-induced liver injury. Mice with hepatocyte-specific beta-catenin deletion (KO) and littermate controls were(More)
UNLABELLED The Wnt signaling pathway is essential for a wide array of developmental and physiological processes. Wnts are extracellular ligands that bind to frizzled (Fz) receptors at the membrane, canonically inducing beta-catenin nuclear translocation and activation. Although beta-catenin has been shown to be critical in liver biology, the expression of(More)
From sunspot drawings provided by the Kanzelhöhe Solar Observatory, Austria, and the Skalnaté Pleso Observatory, Slovak Republic, we extracted a data catalogue of hemispheric Sunspot Numbers covering the time span 1945−2004. The validated catalogue includes daily, monthlymean, and smoothed-monthly relative sunspot numbers for the northern and southern(More)
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