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BACKGROUND/AIMS Inhibition of hepatoma cells by cyclooxygenase (COX)-2-dependent and -independent mechanisms has been shown previously. Here, we examine the effect of Celecoxib, a COX-2-inhibitor and R-Etodolac, an enantiomer of the nonsteroidal anti-inflammatory drug Etodolac, which lacks COX-inhibitory activity, on the Wnt/beta-catenin pathway and human(More)
From sunspot drawings provided by the Kanzelhöhe Solar Observatory, Austria, and the Skalnaté Pleso Observatory, Slovak Republic, we extracted a data catalogue of hemispheric Sunspot Numbers covering the time span 1945−2004. The validated catalogue includes daily, monthly-mean, and smoothed-monthly relative sunspot numbers for the northern and southern(More)
UNLABELLED The Wnt signaling pathway is essential for a wide array of developmental and physiological processes. Wnts are extracellular ligands that bind to frizzled (Fz) receptors at the membrane, canonically inducing beta-catenin nuclear translocation and activation. Although beta-catenin has been shown to be critical in liver biology, the expression of(More)
Although the role of Wnt/beta-catenin signaling in liver growth and development is well established, its contribution in non-neoplastic hepatic pathologies has not been investigated. Here, we examine the role of beta-catenin in a murine model of diet-induced liver injury. Mice with hepatocyte-specific beta-catenin deletion (KO) and littermate controls were(More)
From sunspot drawings provided by the Kanzelhöhe Solar Observatory, Austria, and the Skalnaté Pleso Observatory, Slovak Republic, we extracted a data catalogue of hemispheric Sunspot Numbers covering the time span 1945–2004. The validated catalogue includes daily, monthly-mean, and smoothed-monthly relative sunspot numbers for the northern and southern(More)
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