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PURPOSE Our goal was to determine whether visual system responses to sildenafil accompany shifts in ocular perfusion. The human choroid, which supports the metabolic function of the outer retina, is an erectile tissue, analogous in many respects to the corpus cavenosum. METHODS Right eyes of 12 normal adults were evaluated before and 2 h after 50 mg oral(More)
Perinatal cortical damage is often associated with significant overall shrinkage of the remaining cortex and severe behavioral impairments. Environmental experience was manipulated in order to determine if the anatomical and behavioral effects of neonatal frontal decortication might be attenuated by rearing in a complex environment. Rats received frontal(More)
OBJECTIVE To determine the level of physical activity participants are able to perform at a minimum of 1 year after primary total hip or knee replacement. DESIGN Cross-sectional survey. SETTING A tertiary care arthroplasty center. PARTICIPANTS A total of 170 primary total hip and 184 primary total knee arthroplasty patients. INTERVENTIONS The(More)
The primary objectives of this double-blind study were to compare the antihypertensive efficacy and tolerability of irbesartan and losartan, two angiotensin II (AT1 subtype) receptor antagonists with different pharmacokinetic profiles in patients with mild-to-moderate hypertension. Both drugs are approved for once-daily use (although losartan may also be(More)
We describe the management of a 49-year-old woman who ingested 1,200 mg diltiazem and 500 mg metoprolol. The patient was bradycardic and hypertensive, requiring large doses of inotropic agents and temporary transvenous pacing. Charcoal hemoperfusion was used as an adjunct technique to hasten drug elimination; it rapidly lowered plasma drug levels, with a(More)
PURPOSE To determine by a pilot study whether standard treatment with the topical carbonic anhydrase inhibitor dorzolamide hydrochloride influences visual function under normal breathing conditions, during carbon dioxide inhalation, or during hyperventilation, and to establish criteria for future larger-scale studies. METHODS We enrolled 12 normal(More)
Continuous ambulatory peritoneal dialysis is a new and increasingly popular method of routine dialysis, but its effect on renal transplantation is uncertain. A non-randomised comparison was made of the outcome of grafting in patients who had been treated before transplantation with continuous ambulatory peritoneal dialysis with that in patients treated with(More)
A case report of an endotracheal tube fire occurring during electrodissection tonsillectomy is presented. The authors believe that this incident occurred because a retrograde leak of ventilating gases around an uncuffed endotracheal tube during positive-pressure ventilation produced a high oxygen concentration in the mouth, allowing indirect ignition of the(More)
In this study we compared substrate use at submaximal intensities of a maximal graded exercise test (GXT) with that derived from equivalent intensities during continuous submaximal steady-state exercise in obese and normal-weight women. Sedentary obese (n = 20, body fat > 30%) and normal-weight (n = 15, body fat < or =30%) women performed three treadmill(More)