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The authors have examined the relation between a common A-4T 1890 variant at the cholinergic muscarinic 2 receptor (CHRM2) gene and total IQ in 828 adults. There was a significant progressive linear relation between the three genotypes and increasing total IQ (from 102.8 to 106.8, P0.0045). There was a comparable relation with years of education. The(More)
SIR – Heritability estimates for intelligence quotient (IQ) range from 0.50 to 0.80. This makes IQ a suitable target for attempts to identify the specific genes involved. This first such gene to be identified was by Chorney et al. They reported an association between the insulin-like growth factor 2 receptor (IGF2R) gene and IQ. Cholinergic pathways have(More)
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