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X-ray crystallographic methods and electron microscope image analysis have been used to correlate the structure and the chemical composition of gap junction plaques isolated intact from mouse liver. The requirement that the interpretations of X-ray, electron microscope, and chemical measurements be consistent reduces the uncertainties inherent in the(More)
Twenty-five patients who had histologically proved osteoid osteoma and whose major symptom was joint pain were studied. Retrospective study of clinical data and radiographs revealed that almost all of the lesions were located near the painful joint and that there had been significant delay in determination of the correct diagnosis. The delay was related to(More)
Models for the spatial distribution of protein, lipid and water in gap junction structures have been constructed from the results of the analysis of X-ray diffraction data described here and the electron microscope and chemical data presented in the preceding paper (Caspar, D. L. D., D. A. Goodenough, L. Makowski, and W.C. Phillips. 1977. 74:605-628). The(More)
Models for the spatial distribution of protein, lipid and water in gap junction structures have been constructed from the results of the analysis of X-ray diffrac-tion data described here and the electron microscope and chemical data presented in the preceding paper The continuous intensity distribution on the meridian of the X-ray diffraction pattern was(More)
Correlation of structural changes in isolated gap junctions with the mechanism of channel gating is complicated by the effects of isolation procedures and the lack of a direct functional assay. The effect of variations in the isolation procedure are examined by comparison of the structures of gap junctions isolated by different protocols. X-ray diffraction(More)
X-ray diffraction patterns have been recorded from partially oriented specimens of gap junctions isolated from mouse liver and suspended in sucrose solutions of different concentration and thus of different electron density. Analysis of these diffraction patterns has shown that sucrose is excluded from the 6-fold rotation axis of the junction lattice for a(More)
A retrospective review was made of the pretreatment radiographs of 20 patients with well-documented primary lymphoma of bone. Nine radiographic signs were defined, and the presence or absence of each was recorded for each patient. When the radiographic findings were compared with disease-free survival for each patient, it was found that patients who had a(More)
Component loosening of prosthetic hip replacements was evaluated solely by plain films in 56 patients and solely by arthrography in 49. Radiographic results and surgical findings were compared in all cases. Arthrography was associated with fewer errors. For acetabular component loosening, there were 11% fewer errors made by arthrography (26% versus 15%).(More)
The terms of medical decision making (i.e., accuracy, sensitivity, specificity, predictive value, false positive/negative rates) are often seen in the radiologic literature. The interrelationships among these terms are explained, with special emphasis on the following: (1) How useful a procedure is for detecting/excluding disease depends on sensitivity,(More)
Review of 190 consecutive fractures of the distal radius revealed 14 instances of ligamentous carpal instability (7.4%). Instability was more likely to occur in older patients but was not related to the degree of fracture displacement. There was an association between instability and radial styloid fracture, and in five of nine Colles fractures a separate(More)