WA De Backer

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Oxidative stress in acute respiratory distress syndrome (ARDS) is considered as an important pathophysiological mechanism in acute impairment of lung function. The present study investigated whether a pulmonary oxidant-antioxidant imbalance is indicated by substantial oxidative modification of proteins in bronchoalveolar lavage (BAL) fluid. Oxidatively(More)
The importance of the underlying local and systemic oxidative stress and inflammation in chronic obstructive pulmonary disease (COPD) has long been established. In view of the lack of therapy that might inhibit the progress of the disease, there is an urgent need for a successful therapeutic approach that, through affecting the pathological processes, will(More)
BACKGROUND Salbutamol and ipratropium bromide improve lung function in patients with chronic obstructive pulmonary disease (COPD). However, their bronchodilating effect has not yet been compared in the central and distal airways. Functional imaging using computational fluid dynamics offers the possibility of making such a comparison. The objective of this(More)
INTRODUCTION Noninvasive ventilation (NIV) is a well-established treatment for acute-on- chronic respiratory failure in hypercapnic COPD patients. Less is known about the effects of a long-term treatment with NIV in hypercapnic COPD patients and about the factors that may predict response in terms of improved oxygenation and lowered CO(2) retention. (More)
Aim of the study Aim of the present study was to evaluate the usefulness of a prolonged treatment with low dose acetazolamide in a group of highly selected patients with idiopathic central apnea syndrome. Previous reports have indicated that high dose acetazolamide reduces the number of central apneas (1), but was accompanied by by rather severe acidosis(More)
Careful analysis of the EEG in obstructive sleep apnea (OSA) patients according to the Rechtschaffen and Kales (R & K) criteria indicates that obstructive apneas (OA) are more frequently observed during stage 1 and 2 sleep than during slow wave sleep. However it is also obvious that OA can be recognised during R & K wakefulness stage (St W). The purpose of(More)
Reflexes originated from the supralaryngeal airways, larynx and lungs can affect upper airway calibre r 11. Specific receptors at the lnry ngeal level have been thought to be involved 12J. N~tsal obstruction in normal men m<\y cause apnoeas allll in addition. more arousals and full awakenings from sleep [3]. The underlying mechanism remains unclear. It was(More)
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