WA De Backer

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Determination of the apnea hypopnea index (AHI) as a measure of the severity of obstructive sleep apnea/hypopnea syndrome (OSAHS) is a widely accepted methodology. However, the outcome of such a determination depends on the method used, is time consuming and insufficient for prediction of the effect of all treatment modalities. For these reasons more(More)
BACKGROUND Hypoglossal nerve stimulation has been demonstrated to relieve upper airway obstruction acutely, but its effect on obstructive sleep apnea is not known. OBJECTIVE To determine the response in obstructive sleep apnea to electrical stimulation of the hypoglossal nerve. METHODS Eight patients with obstructive sleep apnea were implanted with a(More)
In order to develop efficient therapeutic regimes for chronic obstructive pulmonary disease (COPD), N-acetylcysteine (NAC) has been tested as a medication which can suppress various pathogenic processes in this disease. Besides its well-known and efficient mucolytic action, NAC meets these needs by virtue of its antioxidant and anti-inflammatory modes of(More)
The aim of this investigation was to study the geographic variation in sleep complaints and to identify risk factors for sleep disturbances in three European countries: Iceland (Reykjavik), Sweden (Uppsala and Göteborg) and Belgium (Antwerp). The study involved a random population of 2,202 subjects (age 20-45 years) who participated in the European(More)
Obstructive sleep apnoea (OSA) is considered as a risk factor for the development of arterial hypertension, coronary artery disease (CAD), myocardial infarction and stroke. These clinical manifestations are the consequences of elevated sympathetic activity, cardiovascular variability, intrathoracic pressure changes, inflammation, oxidative stress,(More)
Obstructive sleep apnea (OSA) can be associated with depressed hypercapnic ventilatory response (HCVR) (White D.P., N.J. Douglas, C.K. Pickett, C.W. Willich and J.V. Weil, Am. Rev. Respir. Dis 128:984-986, 1983), which might be responsible for aggravating the sleep-related breathing disorder (SRBD). The present study evaluated whether in patients with(More)
Mandibular advancement devices (MADs) have emerged as a popular alternative for the treatment of sleep-disordered breathing. These devices bring the mandibula forward in order to increase upper airway (UA) volume and prevent total UA collapse during sleep. However, the precise mechanism of action appears to be quite complex and is not yet completely(More)
A sensitive and specific radioimmunoassay was used to measure interleukin 8 (IL-8) in bronchoalveolar lavage fluids from control subjects, patients with the adult respiratory distress syndrome (ARDS) and patients undergoing coronary bypass surgery, a risk factor for developing ARDS. Concentrations of IL-8, albumin, total protein and numbers of neutrophils(More)
AIM Only a limited number of studies, designed to establish normal values for sleep-related respiratory variables in children, have been reported, and all are non-European. The aim of this study was to expand the knowledge on normative data in children. METHODS Subjects ranging from 6 to 16 years were recruited and underwent full polysomnography. Only(More)
Computational fluid dynamics (CFD) is increasingly applied in the respiratory domain. The ability to simulate the flow through a bifurcating tubular system has increased the insight into the internal flow dynamics and the particular characteristics of respiratory flows such as secondary motions and inertial effects. The next step in the evolution is to(More)