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The importance of the underlying local and systemic oxidative stress and inflammation in chronic obstructive pulmonary disease (COPD) has long been established. In view of the lack of therapy that might inhibit the progress of the disease, there is an urgent need for a successful therapeutic approach that, through affecting the pathological processes, will(More)
BACKGROUND Salbutamol and ipratropium bromide improve lung function in patients with chronic obstructive pulmonary disease (COPD). However, their bronchodilating effect has not yet been compared in the central and distal airways. Functional imaging using computational fluid dynamics offers the possibility of making such a comparison. The objective of this(More)
INTRODUCTION Noninvasive ventilation (NIV) is a well-established treatment for acute-on- chronic respiratory failure in hypercapnic COPD patients. Less is known about the effects of a long-term treatment with NIV in hypercapnic COPD patients and about the factors that may predict response in terms of improved oxygenation and lowered CO(2) retention. (More)
Careful analysis of the EEG in obstructive sleep apnea (OSA) patients according to the Rechtschaffen and Kales (R & K) criteria indicates that obstructive apneas (OA) are more frequently observed during stage 1 and 2 sleep than during slow wave sleep. However it is also obvious that OA can be recognised during R & K wakefulness stage (St W). The purpose of(More)
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