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Sodium-specific membrane channels of frog skin are pores: current fluctuations reveal high turnover.
The reversible sodium transport blocker amiloride causes current fluctuations at the apical membrane of the outer stratum granulosum of frog skin. Their power density spectra reveal that singleExpand
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ATP release through connexin hemichannels in corneal endothelial cells.
PURPOSE Intercellular Ca(2+) wave propagation is a distinct form of cell-cell communication. In corneal endothelial cells, intercellular Ca(2+) wave propagation evoked by a point mechanical stimulusExpand
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The role of K+ channels in colonic Cl- secretion.
Cl- secretion in the rat colonic crypt base cell (bc) requires the coordinated (a) opening of Cl- channels in the luminal membrane; (b) activation of the Na+2Cl-K+ cotransporter; (c) enhancedExpand
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Cu2+ reveals different binding sites of amiloride and CDPC on the apical Na channel of frog skin.
The effect of Cu2+ ions, present in the mucosal bathing solution, on the transepithelial short-circuit current (Isc) and conductance (Gt) and on the blocker-induced noise of apical Na channels, wasExpand
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Activation and blockage of a calcium‐sensitive cation‐selective pathway in the apical membrane of toad urinary bladder.
1. The properties of cation movements through a previously described Ca2+‐sensitive oxytocin‐stimulated pathway in the apical membrane of the toad urinary bladder were further investigated. 2. In theExpand
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Capacitance measurements reveal different pathways for the activation of CFTR
Abstract. We used the Xenopus laevis oocyte expression system to characterize adenosine 3',5'-cyclic monophosphate (cAMP) activation of the cystic fibrosis transmembrane conductance regulator (CFTR).Expand
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Isovolumetric regulation in a distal nephron cell line (A6).
The effects of gradually reducing the osmolality of the basolateral solution (pi b) were examined in a renal epithelial cell line (A6). pi b was linearly decreased with time from 260 to 140 mosmol/Expand
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Ionic channels in epithelial cell membranes.
This review focused on results obtained with methods that allow studies of ionic channels in situ, namely, patch clamping and current-noise analysis. We reported findings for ionic channels in apicalExpand
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Evidence for apical sodium channels in frog lung epithelial cells.
To reveal the mechanism of Na+ transport across Xenopus lung epithelium, we recorded short-circuit current (Isc), transepithelial resistance (Rt), and current noise spectra while the isolated lungExpand
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Loss of nucleotide regulation of epithelial chloride transport in the jejunum of P2Y4-null mice.
The P2Y(4) receptor is responsive to UTP in human and to ATP and UTP in rodents. With the aim of identifying its pharmacotherapeutic interest, we generated P2Y(4)-null mice by a classic geneExpand
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