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Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1.
Phosphorylation sites in members of the protein kinase A (PKA), PKG, and PKC kinase subfamily are conserved. Thus, the PKB kinase PDK1 may be responsible for the phosphorylation of PKC isotypes. PDK1Expand
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The structure and regulation of vinculin.
Vinculin is a ubiquitously expressed actin-binding protein frequently used as a marker for both cell-cell and cell-extracellular matrix (focal adhesion) adherens-type junctions, but its function hasExpand
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Multiple pathways control protein kinase C phosphorylation
The protein kinase C (PKC) family of signal transducers are characterized by a dependence upon lipids for activity. Specifically, the classical (cPKCα, β and γ) and novel (nPKCδ, ϵ, η and θ) PKCExpand
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Vinculin acts as a sensor in lipid regulation of adhesion-site turnover
The dynamics of cell adhesion sites control cell morphology and motility. Adhesion-site turnover is thought to depend on the local availability of the acidic phospholipidExpand
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Mapping and Consensus Sequence Identification for Multiple Vinculin Binding Sites within the Talin Rod*
The interaction between the cytoskeletal proteins talin and vinculin plays a key role in integrin-mediated cell adhesion and migration. Three vinculin binding sites (VBS1-3) have previously beenExpand
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Mammalian TOR controls one of two kinase pathways acting upon nPKCdelta and nPKCepsilon.
There are three conserved phosphorylation sites in protein kinase C (PKC) isotypes that have been termed priming sites and play an important role in PKC function. The requirements and pathwaysExpand
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Activation of a vinculin‐binding site in the talin rod involves rearrangement of a five‐helix bundle
The interaction between the cytoskeletal proteins talin and vinculin plays a key role in integrin‐mediated cell adhesion and migration. We have determined the crystal structures of two domains fromExpand
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The F-actin Cross-linking and Focal Adhesion Protein Filamin A Is a Ligand and in Vivo Substrate for Protein Kinase Cα*
Filamin A is an established structural component of cell-matrix adhesion sites. In addition, it serves as a scaffold for the subcellular targeting of different signaling molecules. Protein kinase CExpand
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A Lipid-regulated Docking Site on Vinculin for Protein Kinase C*
During cell spreading, binding of actin-organizing proteins to acidic phospholipids and phosphorylation are important for localization and activity of these proteins at nascent cell-matrix adhesionExpand
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Mammalian TOR Controls One of Two Kinase Pathways Acting upon nPKCδ and nPKCε*
There are three conserved phosphorylation sites in protein kinase C (PKC) isotypes that have been termed priming sites and play an important role in PKC function. The requirements and pathwaysExpand
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