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Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity
Autophagy is characterized by the sequestration of bulk cytoplasm, including damaged proteins and organelles, and delivery of the cargo to lysosomes for degradation. Although the autophagic pathway… Expand
Surf the Post-translational Modification Network of p53 Regulation
Among the human genome, p53 is one of the first tumor suppressor genes to be discovered. It has a wide range of functions covering cell cycle control, apoptosis, genome integrity maintenance,… Expand
p53: Structure, Function and Therapeutic Applications
Since the p53 tumor suppressor gene has been found to be mutated in more than 50% of human cancers, it has attracted the interest of numerous researchers. The capacity of p53 for multiple biological… Expand
Acetylation of p53 at Lysine 373/382 by the Histone Deacetylase Inhibitor Depsipeptide Induces Expression of p21Waf1/Cip1
ABSTRACT Generally, histone deacetylase (HDAC) inhibitor-induced p21Waf1/Cip1 expression is thought to be p53 independent. Here we found that an inhibitor of HDAC, depsipeptide (FR901228), but not… Expand
The comet assay: a sensitive method for detecting DNA damage in individual cells.
The comet assay is a sensitive and rapid method for DNA strand break detection in individual cells, and the year 2009 represents the 25th anniversary of the first description of this methodology in… Expand
Methylation of Adjacent CpG Sites Affects Sp1/Sp3 Binding and Activity in the p21Cip1 Promoter
- W. Zhu, Kanur Srinivasan, +7 authors G. Otterson
- Biology, Medicine
- Molecular and Cellular Biology
- 15 June 2003
ABSTRACT DNA methylation in the promoter of certain genes is associated with transcriptional silencing. Methylation affects gene expression directly by interfering with transcription factor binding… Expand
Autophagy Regulates Chromatin Ubiquitination in DNA Damage Response through Elimination of SQSTM1/p62.
Autophagy is an intracellular degradation system that delivers cytoplasmic constituents to the lysosome, and loss of autophagy has been linked to increased genome instability. Here, we report that… Expand
Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses
The tumour suppressor ARF is specifically required for p53 activation under oncogenic stress. Recent studies showed that p53 activation mediated by ARF, but not that induced by DNA damage, acts as a… Expand
Applications of post-translational modifications of FoxO family proteins in biological functions.
The functions of the FoxO family proteins, in particular their transcriptional activities, are modulated by post-translational modifications (PTMs), including phosphorylation, acetylation,… Expand
5-Aza-2′-deoxycytidine Activates the p53/p21Waf1/Cip1 Pathway to Inhibit Cell Proliferation*
- W. Zhu, T. Hileman, +8 authors G. Otterson
- Biology, Medicine
- Journal of Biological Chemistry
- 9 April 2004
In addition to its demethylating function, 5-aza-2′-deoxycytidine (5-aza-CdR) also plays an important role in inducing cell cycle arrest, differentiation, and cell death. However, the mechanism by… Expand