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Automated eukaryotic gene structure annotation using EVidenceModeler and the Program to Assemble Spliced Alignments
TLDR
The experiments on both rice and human genome sequences demonstrate that EVM produces automated gene structure annotation approaching the quality of manual curation. Expand
Programming and Inheritance of Parental DNA Methylomes in Mammals
TLDR
It is found that 5mC or its oxidized derivatives, at the majority of demethylated CpGs, are converted to unmodified cytosines independent of passive dilution from gametes to four-cell embryos. Expand
The Institute for Genomic Research Osa1 Rice Genome Annotation Database1
TLDR
A series of functional data types has been annotated for the rice genome that includes alignment with genetic markers, assignment of gene ontologies, identification of flanking sequence tags, alignment with homologs from related species, and syntenic mapping with other cereal species. Expand
The molecular basis of IL-21-mediated proliferation.
TLDR
Data indicate the involvement of the Jak-STAT, MAPK, and PI3K pathways in IL-21 signaling and the role of tyrosine residues in theIL-21R cytoplasmic domain is investigated. Expand
miR‐181b modulates multidrug resistance by targeting BCL2 in human cancer cell lines
TLDR
The findings suggest that miR‐181b could play a role in the development of MDR in both gastric and lung cancer cell lines, at least in part, by modulation of apoptosis via targeting BCL2. Expand
Comparative genomics and functional analysis of niche-specific adaptation in Pseudomonas putida
TLDR
Comparative genomics provided a powerful tool to gain new insights into the adaptation of P. putida to specific lifestyles and environmental niches, and clearly demonstrated that horizontal gene transfer played a key role in this adaptation process. Expand
Arginine Methylation of STAT1 Modulates IFNα/β-Induced Transcription
TLDR
Arginine methylation of STAT1 is an additional posttranslational modification regulating transcription factor function, and alteration of argininemethylation might be responsible for the lack of interferon responsiveness observed in many malignancies. Expand
DNA methylation predicts survival and response to therapy in patients with myelodysplastic syndromes.
TLDR
Although methylation at baseline did not correlate with clinical response to decitabine, a significant correlation between reduced methylation over time and clinical responses was observed. Expand
miR-497 modulates multidrug resistance of human cancer cell lines by targeting BCL2
TLDR
The findings first suggested that has-miR-497 could play a role in both gastric and lung cancer cell lines at least in part by modulation of apoptosis via targeting BCL2. Expand
The TIGR Plant Transcript Assemblies database
TLDR
The TIGR Plant Transcript Assemblies (TA) database uses expressed sequences collected from the NCBI GenBank Nucleotide database for the construction of transcript assemblies, which includes all plant species for which more than 1000 EST or cDNA sequences are publicly available. Expand
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