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MicroRNA-181a sensitizes human malignant glioma U87MG cells to radiation by targeting Bcl-2.
Radiotherapy is widely used in cancer treatment and biological studies. Multiple mechanisms induced by radiation, especially changes of the expression profile of genes, lead to the disruption ofExpand
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Identification of a Nuclear Stat1 Protein Tyrosine Phosphatase
ABSTRACT Upon interferon (IFN) stimulation, Stat1 becomes tyrosine phosphorylated and translocates into the nucleus, where it binds to DNA to activate transcription. The activity of Stat1 isExpand
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Exosomes derived from human umbilical cord mesenchymal stem cells alleviate liver fibrosis.
Mesenchymal stem cells (MSCs) have been considered as an attractive tool for the therapy of diseases. Exosomes excreted from MSCs can reduce myocardial ischemia/reperfusion damage and protect againstExpand
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Mesenchymal Stern Cells from Adult Human Bone Marrow Differentiate into a Cardiomyocyte Phenotype In Vitro
A method for isolating adult human bone marrow mesenchymal stem cells (MSCs) was established, and the ability of human MSCs to differentiate into cells with characteristics of cardiomyocytes in vitroExpand
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HucMSC‐Exosome Mediated‐Wnt4 Signaling Is Required for Cutaneous Wound Healing
Mesenchymal stem cell‐derived exosomes (MSC‐Ex) play important roles in tissue injury repair, however, the roles of MSC‐Ex in skin damage repair and its mechanisms are largely unknown. Herein, weExpand
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Exosomes derived from human bone marrow mesenchymal stem cells promote tumor growth in vivo.
Mesenchymal stem cells (MSCs) can promote tumor growth in a mouse xenograft model, but the exact mechanism remains unclear. In this study, we investigated the effects of bone marrow MSC-derivedExpand
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Human Umbilical Cord Mesenchymal Stem Cell Exosomes Enhance Angiogenesis Through the Wnt4/β‐Catenin Pathway
Human umbilical cord mesenchymal stem cells (hucMSCs) and their exosomes have been considered as potential therapeutic tools for tissue regeneration; however, the underlying mechanisms are still notExpand
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Rat pregnane X receptor: molecular cloning, tissue distribution, and xenobiotic regulation.
An orphan nuclear receptor, termed the pregnane X receptor (PXR), has recently been cloned from mouse and human and defines a novel steroid signaling pathway (Cell 92, 73-82, 1998; Proc. Natl. Acad.Expand
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Identification of a Nuclear Stat 1 Protein Tyrosine Phosphatase
Identification of a Nuclear Stat1 Protein Tyrosine Phosphatase Johanna ten Hoeve, Maria de Jesus Ibarra-Sanchez, Yubin Fu, Wei Zhu, Michel Tremblay, Michael David, and Ke Shuai* Department ofExpand
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miR-181a/b significantly enhances drug sensitivity in chronic lymphocytic leukemia cells via targeting multiple anti-apoptosis genes.
MicroRNAs (miRNAs) have been shown to play critical roles in regulating the progress of leukemia. We performed miRNA expression profile in six Chinese patients with chronic lymphocytic leukemiaExpand
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