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Laser-capture microdissection
Deciphering the cellular and molecular interactions that drive disease within the tissue microenvironment holds promise for discovering drug targets of the future. In order to recapitulate the inExpand
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Circulating autoantibodies to phosphorylated α-enolase are a hallmark of pancreatic cancer.
Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis and no diagnostic markers have, as of yet, been defined. In PDAC patients, α-enolase (ENOA) is up-regulated and elicits the productionExpand
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Investigation of the Ovarian and Prostate Cancer Peptidome for Candidate Early Detection Markers Using a Novel Nanoparticle Biomarker Capture Technology
Current efforts to identify protein biomarkers of disease use mainly mass spectrometry (MS) to analyze tissue and blood specimens. The low-molecular-weight “peptidome” is an attractive informationExpand
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Methylselenol prodrug enhances MDV3100 efficacy for treatment of castration‐resistant prostate cancer
The next‐generation antiandrogen MDV3100 prolongs overall survival of patients with metastatic castration‐resistant prostate cancer (CRPC). However, patient responses are variable, and survivalExpand
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Trainable immunohistochemical HER2/neu image analysis: a multisite performance study using 260 breast tissue specimens.
CONTEXT Aperio Technologies, Inc (Vista, California) provides a new immunohistochemistry (IHC) HER2 Image Analysis (IA) system that allows tuning of the intensity thresholds of the HER2/ neu scoringExpand
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A New Immunohistochemical ER/PR Image Analysis System: A Multisite Performance Study
BackgroundAperio provides a new image analysis (IA) solution for immunohistochemistry (IHC) as part of its digital pathology system. To be used in a clinical setting, substantial equivalence toExpand
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Reading Immunohistochemical Slides on a Computer Monitor—A Multisite Performance Study Using 180 HER2-stained Breast Carcinomas
BackgroundWith the adoption of digital pathology, image analysis (IA) of immunohistochemistry (IHC) slides can be integrated seamlessly into the digital pathology workflow. A pathologist can now useExpand
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A multisite performance study comparing the reading of immunohistochemical slides on a computer monitor with conventional manual microscopy for estrogen and progesterone receptor analysis.
A multisite study was conducted to assess the performance of the Aperio digital pathology system (Aperio Technologies, Vista, CA) for reading estrogen receptor (ER) and progesterone receptor (PR)Expand
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miR-1303 promotes the proliferation, migration and invasion of prostate cancer cells through regulating the Wnt/β-catenin pathway by targeting DKK3
MicroRNA-1303 (miR-1303) is involved in the tumorigenesis and progression of several cancers, and yet the role of miR-1303 in prostate cancer (PCa) and its underlying mechanism are unknown. ToExpand
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Suppression of miR-4735-3p in androgen receptor-expressing prostate cancer cells increases cell death during chemotherapy.
MicroRNAs (miRNAs) play critical roles in the tumorigenesis of prostate cancer, while the biological function of miR-4735-3p is unknown. Mitogen-activated protein kinase kinase kinase 1 (MEKK1) hasExpand
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