• Publications
  • Influence
Predominant role for C5b-9 in renal ischemia/reperfusion injury.
TLDR
The membrane attack complex of complement (in which C5 and C6 participate) may account for the effect of complement on mouse renal I/R injury and is a potential target for prevention of I-R injury in this model. Expand
Mathematical Modelling of Immune Response in Tissues
TLDR
The PDE model is robust to variation in antigen load and it can account for the elimination of antigen and subsequent resolution of the immune response or equilibrium of theimmune response to the presence of persistent antigen and the formation of a granuloma. Expand
Inflammation and platelet‐activating factor production during hepatic ischemia/reperfusion
TLDR
It is concluded that platelet‐activating factor contributes to the inflammatory consequences of ischemia/reperfusion underlying late‐phase hepatic injury. Expand
Contribution of renal secreted complement C3 to the circulating pool in humans.
TLDR
It is demonstrated that human transplant kidney in the resting state is a significant source of extrahepatic C3, and its heightened local synthesis during rejection episodes suggests a possible pathogenic role for C3 in this immunological process. Expand
Role of cGMP-dependent protein kinase in regulation of pulmonary vascular smooth muscle cell adhesion and migration: effect of hypoxia.
TLDR
CGMP/PKG1 signaling is identified as central to the functional differences between PVSMC exposed to normoxia versus hypoxia, implying a role for PKG in the modulation of cofilin activity and actin dynamics. Expand
Ischemia/reperfusion injury in the liver of BALB/c mice activates AP-1 and nuclear factor kappaB independently of IkappaB degradation.
TLDR
The findings suggest that phosphorylation may play an important role in regulating AP-1 transcriptional complexes and suggest that JNK, IkappaB tyrosine kinase, and JunD are potential targets for therapeutic intervention during liver I/R injury. Expand
Interaction of angiotensin II and mechanical stretch on vascular endothelial growth factor production by human mesangial cells.
TLDR
Investigation of the effect of TGF-beta blockade, angiotensin II (AngII), and the interaction between AngII and stretch on human mesangial cell VEGF production finds mechanical stretch upregulates the AT1 receptor, enhancing the cellular response to AngII. Expand
Intrarenal synthesis of complement.
TLDR
Evidence is reviewed that the kidney has the capacity to synthesize most of the activation pathway components of the complement cascade and a case for more definitive investigation of these functions is presented. Expand
Role of platelet-activating factor in hepatic responses after bile duct ligation in rats.
TLDR
It is indicated that endogenous PAF may be an important signaling mediator for the hepatic inflammatory alterations associated with short-term bile duct ligation and that the interaction of Kupffer cells with portal endotoxin is the mechanism by which PAF is produced locally. Expand
Apical proteins stimulate complement synthesis by cultured human proximal tubular epithelial cells.
TLDR
The production of complement by human proximal tubular epithelial cells exposed to serum proteins at the apical surface is characterized to provide a possible mechanism for the link between proteinuria and interstitial fibrosis. Expand
...
1
2
3
4
...