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Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma
TLDR
Evidence is reported that suggests that the number of HBV integrations is associated with patient survival and copy-number variations were significantly increased at HBV breakpoint locations where chromosomal instability was likely induced.
View on Nature
Inducer-stimulated Fas targets activated endothelium for destruction by anti-angiogenic thrombospondin-1 and pigment epithelium–derived factor
TLDR
It is shown that two natural inhibitors of angiogenesis, thrombospondin-1 and pigment epithelium–derived factor, derive specificity for remodeling vessels from their dependence on Fas/Fas ligand (FasL)-mediated apoptosis to blockAngiogenesis.
View on Nature
The Sjögren’s Syndrome-Associated Autoantigen Ro52 Is an E3 Ligase That Regulates Proliferation and Cell Death1
TLDR
The increased expression of the Ro52 autoantigen in patients may be directly involved in the reduced cellular proliferation and increased apoptotic cell death observed in Sjögren’s syndrome and SLE, and may thus contribute to theAutoantigenic load and induction of autoimmune B and T cell responses observed in rheumatic patients.
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FOXO1/3 and PTEN Depletion in Granulosa Cells Promotes Ovarian Granulosa Cell Tumor Development.
TLDR
Results provide strong evidence that impaired functions of the FOXO1/3/PTEN pathways lead to dramatic changes in the molecular program within granulosa cells, chronic activin signaling in the presence of FOXL2 and GATA4, and tumor formation.
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CD36 palmitoylation disrupts free fatty acid metabolism and promotes tissue inflammation in non-alcoholic steatohepatitis.
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Pentatricopeptide-repeat family protein RF6 functions with hexokinase 6 to rescue rice cytoplasmic male sterility
TLDR
The identification of RF6 is identified as a novel pentatricopeptide repeat family protein that restores the fertility of Honglian CMS (HL-CMS), a major type of rice CMS used in breeding, and insight is provided into the function of hexokinase 6 in regulating mitochondrial RNA metabolism and may facilitate further exploitation of heterosis in rice.
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A commensal strain of Staphylococcus epidermidis protects against skin neoplasia
TLDR
The discovery that strains of Staphylococcus epidermidis produce 6-N-hydroxyaminopurine (6-HAP), a molecule that inhibits DNA polymerase activity, shows a new role for skin commensal bacteria in host defense.
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Cloning and expression analysis of a transformer gene in Daphnia pulex during different reproduction stages.
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EF24, a novel curcumin analog, disrupts the microtubule cytoskeleton and inhibits HIF-1
TLDR
This study identifies EF24 as a novel curcumin-related compound possessing a distinct mechanism of action, which it believes contributes to the potent anticancer activity of this agent and can be further exploited to investigate the therapeutic potential of EF24.
View on Taylor & Francis
Tuning of human MAIT cell activation by commensal bacteria species and MR1 dependent T cell presentation
TLDR
An in vitro functional assay through human T cells engineered for MAIT-TCRs stimulated by MR1-expressing antigen-presenting cells (APCs) suggests that MAIT cells can discriminate and categorize complex human microbiota through computation of TCR signals depending on antigen load and presenting cells, and fine-tune their functional responses.
View on Springer
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