Pharmacologic inhibition of cyclin-dependent kinases 4 and 6 arrests the growth of glioblastoma multiforme intracranial xenografts.
- K. Michaud, D. Solomon, T. Waldman
- Medicine, BiologyCancer Research
- 15 April 2010
The results support clinical trial evaluation of PD-0332991 against newly diagnosed as well as recurrent GBM, and indicate that Rb status is the primary determinant of potential benefit from this therapy.
Binding mechanism of coronavirus main proteinase with ligands and its implication to drug design against SARS
- K. Chou, Dongqing Wei, W. Zhong
- ChemistryBiochemical and Biophysical Research…
- 17 July 2003
SU14813: a novel multiple receptor tyrosine kinase inhibitor with potent antiangiogenic and antitumor activity
- S. Patyna, A. Laird, D. Hu-Lowe
- Biology, ChemistryMolecular Cancer Therapeutics
- 1 July 2006
Substantial data support the ongoing phase I clinical evaluation of SU14813 in advanced malignancies, a small molecule identified from the same chemical library used to isolate sunitinib, has broad-spectrum RTK inhibitory activity through binding to and inhibition of VEGFR, PDGFR, KIT, and FLT3.
The Pharmacologic Basis of the Cardiovascular Toxicity of Minoxidil in the Dog
- G. Mesfin, F. G. Robinson, M. Higgins, W. Zhong, D. Ducharme
- Medicine, BiologyToxicologic pathology (Print)
- 1 July 1995
The cardiovascular toxicity of MNX in dogs is not caused by a direct toxic effect ofMNX on the heart but apparently is related to the exaggerated pharmacologic/profound hemodynamic effects it elicits in the dog.
Simultaneous quantitation of pioglitazone and its metabolites in human serum by liquid chromatography and solid phase extraction.
- W. Zhong, M. Williams
- ChemistryJournal of Pharmaceutical and Biomedical Analysis
- 1 February 1996
Discovery and Characterization of QPT-1, the Progenitor of a New Class of Bacterial Topoisomerase Inhibitors
- Alita A. Miller, G. Bundy, M. R. Barbachyn
- BiologyAntimicrobial Agents and Chemotherapy
- 1 August 2008
Biochemical and genetic characterization showed that the QPT-1 targets the β subunit of bacterial type II topoisomerases via a mechanism of inhibition distinct from the mechanisms of fluoroquinolones and novobiocin.
Diffusion‐Controlled Reactions of Enzymes
In the study of enzyme-catalysed mechanisms, it is often necessary to calculate the upper limit of enzyme reaction, which is usually used as an important criterion to identify whether an assumed…
Quantitative analysis of PD 0332991 in xenograft mouse tumor tissue by a 96-well supported liquid extraction format and liquid chromatography/mass spectrometry.
- Leslie Nguyen, W. Zhong, C. Painter, Cathy C. Zhang, S. V. Rahavendran, Zhongzhou Shen
- Biology, ChemistryJournal of Pharmaceutical and Biomedical Analysis
- 2 November 2010
Piperazine imidazo[1,5-a]quinoxaline ureas as high-affinity GABAA ligands of dual functionality.
- E. Jacobsen, L. S. Stelzer, J. Mickelson
- Biology, ChemistryJournal of Medicinal Chemistry
- 20 March 1999
From this series emerged two partial agonists which had good activity in anxiolytic models, acceptable pharmacokinetics, and minimal benzodiazepine-type side effects.
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