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Breast cancer-secreted miR-122 reprograms glucose metabolism in pre-metastatic niche to promote metastasis
Reprogrammed glucose metabolism as a result of increased glycolysis and glucose uptake is a hallmark of cancer. Here we show that cancer cells can suppress glucose uptake by non-tumour cells in theExpand
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DDX41 recognizes bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response
The induction of type I interferons by the bacterial secondary messengers cyclic di-GMP (c-di-GMP) or cyclic di-AMP (c-di-AMP) is dependent on a signaling axis that involves the adaptor STING, theExpand
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Pseudomonas syringae type III effector HopZ1 targets a host enzyme to suppress isoflavone biosynthesis and promote infection in soybean.
Type III secreted effectors (T3SEs), such as Pseudomonas syringae HopZ1, are essential bacterial virulence proteins injected into the host cytosol to facilitate infection. However, few direct targetsExpand
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Nanomaterials in fluorescence-based biosensing
  • W. Zhong
  • Chemistry, Medicine
  • Analytical and bioanalytical chemistry
  • 17 February 2009
Fluorescence-based detection is the most common method utilized in biosensing because of its high sensitivity, simplicity, and diversity. In the era of nanotechnology, nanomaterials are starting toExpand
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Two-photon graphene oxide/aptamer nanosensing conjugate for in vitro or in vivo molecular probing.
Two-photon excitation (TPE) with near-infrared (NIR) photons as the excitation source have the unique properties of lower tissue autofluorescence and self-absorption, reduced photodamage andExpand
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Dissociation-based screening of nanoparticle-protein interaction via flow field-flow fractionation.
A protein corona will be formed on nanoparticles (NPs) entering a biological matrix, which can influence particles' subsequent behaviors inside the biological systems. For proteins bound stably toExpand
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Membrane blotting for rapid detection of mercury(II) in water.
A simple and sensitive approach to detect Hg(2+) colorimetrically using blotting membrane is described to detect as low as 0.1 nM Hg(2+) with the aid of a scanner.
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Stand-alone rolling circle amplification combined with capillary electrophoresis for specific detection of small RNA.
Noncoding small RNAs play diverse, important biological roles through gene expression regulation. However, their low expression levels make it difficult to identify new small RNA species and studyExpand
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Size and Surface Functionalization of Iron Oxide Nanoparticles Influence the Composition and Dynamic Nature of Their Protein Corona
Nanoparticles (NPs) adsorb proteins when in the biological matrix, and the resulted protein corona could affect NP-cell interactions. The corona has a dynamic nature with the adsorbed proteinsExpand
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Impact of carrier fluid composition on recovery of nanoparticles and proteins in flow field flow fractionation.
Flow field flow fractionation (F4) is an invaluable separation tool for large analytes, including nanoparticles and biomolecule complexes. However, sample loss due to analyte-channel membraneExpand
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