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Screening for colorectal neoplasms with new fecal occult blood tests: update on performance characteristics.
BACKGROUND One type of fecal occult blood test (FOBT), the unrehydrated guaiac fecal occult blood test (GT), is recommended by the United States Preventive Services Task Force and the Institute ofExpand
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Association Between Time to Colonoscopy After a Positive Fecal Test Result and Risk of Colorectal Cancer and Cancer Stage at Diagnosis
Importance The fecal immunochemical test (FIT) is commonly used for colorectal cancer screening and positive test results require follow-up colonoscopy. However, follow-up intervals vary, which mayExpand
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Variation of adenoma prevalence by age, sex, race, and colon location in a large population: implications for screening and quality programs.
BACKGROUND & AIMS Reliable community-based colorectal adenoma prevalence estimates are needed to inform colonoscopy quality standards and to estimate patient colorectal cancer risks; however, minimalExpand
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Large-Scale Genomic Analyses Link Reproductive Aging to Hypothalamic Signaling, Breast Cancer Susceptibility, and BRCA1-Mediated DNA Repair
ABSTRACT: Menopause timing has a major impact on infertility and risk of disease. Younger age at natural (nonsurgical) menopause (ANM) is associated with a higher risk of osteoporosis, cardiovascularExpand
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Apolipoprotein(a) isoform size, lipoprotein(a) concentration, and coronary artery disease: a mendelian randomisation analysis
Summary Background The lipoprotein(a) pathway is a causal factor in coronary heart disease. We used a genetic approach to distinguish the relevance of two distinct components of this pathway,Expand
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Effectiveness of screening colonoscopy in reducing the risk of death from right and left colon cancer: a large community-based study
Objective Screening colonoscopy's effectiveness in reducing colorectal cancer mortality risk in community populations is unclear, particularly for right-colon cancers, leading to recommendationsExpand
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Fecal Immunochemical Test Program Performance Over 4 Rounds of Annual Screening
Context The fecal immunochemical test is an effective way to screen for colorectal cancer, but we know more about how well it does the first time it is used and less about how well it does in laterExpand
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Air-pollutant chemicals and oxidized lipids exhibit genome-wide synergistic effects on endothelial cells
BackgroundAmbient air pollution is associated with increased cardiovascular morbidity and mortality. We have found that exposure to ambient ultrafine particulate matter, highly enriched in redoxExpand
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Physical activity, smoking, and genetic predisposition to obesity in people from Pakistan: the PROMIS study
BackgroundMultiple genetic variants have been reliably associated with obesity-related traits in Europeans, but little is known about their associations and interactions with lifestyle factors inExpand
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Citalopram provides little or no benefit in nondepressed patients with irritable bowel syndrome.
BACKGROUND & AIMS Data on the benefit of selective serotonin reuptake inhibitors (SSRIs) in irritable bowel syndrome (IBS) are conflicting. The longitudinal relationship between clinical symptoms andExpand
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